Results 91 to 100 of about 85,601 (238)

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Stress and conflict management in core facilities—News from an imaging survey

Journal of Microscopy, EarlyView.
Abstract While conflict management is a well‐known challenge for people working in the service sector, this topic remains largely unexplored in scientific imaging core facilities, despite frequent interactions with diverse users in environments with complex service demands.
Jan Peychl, Chiara Rossi, Nathalie Aulner, Audrey Salles, Nadia Halidi, Maia Brunstein, Adeline Mallet, Karin Aumayr, Jean‐Marc Verbavatz, Thomas Heuser, Rachel Santarella‐Mellwig, Aurelien Dauphin, Eef Parthoens, Manuel Gunkel, Martin Fritsch, Sebastian T Bundschuh, Rym Chaabouni, Agnes Uhereczky, Erin M Tranfield, Pablo Hernández Varas, Sebastian Munck, the Core4Life Consortium   +21 more
wiley   +1 more source

Psychological care for Huntington's disease: A qualitative study exploring interventions in the Netherlands

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Objectives Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by a range of motor, cognitive, and psychiatric symptoms. Psychological symptoms can arise from being at risk for the disease and from its manifestation, necessitating psychological interventions to address the evolving burden, even before onset. This
Kasper F. Van der Zwaan, Laura C. M. Kuijper, Pearl J. C. van Lonkhuizen, Raymund A. C. Roos, Susanne T. de Bot   +4 more
wiley   +1 more source

Aumento de la fertilidad y prolificidad en ovejas pelibuey sincronizadas con FGA e inyección de BST y ECG

Revista Científica, 2021
La hormona del crecimiento bovina (bST) incrementa las con-centraciones séricas del Factor de Crecimiento Insulinoide tipo I (IGF-I). Estas hormonas favorecen el desarrollo folicular, la fer-tilización y la sobrevivencia embrionaria.
Netzi Naidí Méndez-Palacios, Joel Hernández Cerón, Néstor Méndez-Palacios, Felicitas Vázquez-Flores, Maximino Méndez-Mendoza, Alejandro Córdova-Izquierdo   +5 more
doaj  

StALKBH10B‐Mediated RNA m6A Modification Inhibits Potato Salt Tolerance by Targeting Flavonoids and ABA Signalling Pathways

Plant Biotechnology Journal, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) is the most prevalent methylation modification present in mRNAs, which has been confirmed to participate in many developmental and biological processes. However, the biological function and specific regulatory mechanism of m6A modification in relation to salt tolerance of potato remain obscure.
Xuanming Dong, Jianyu Ma, Chenxin Sui, Yan Li, Vadim Khassanov, Hongju Jian, Dianqiu Lv   +6 more
wiley   +1 more source

Serum‐derived albumin as a cryoprotective agent for the long‐term storage of red blood cells: A preliminary examination

Transfusion, EarlyView.
Abstract Background Cryopreservation extends the shelf life of red blood cells (RBC) from weeks to years, offering major advantages for blood banking logistics, especially in remote environments. However, current glycerol‐based methods, though effective, are limited in scope due to complex post‐thaw washing and incompatibility with routine clinical ...
Thomas Bailey‐Schmidt, Christine V. Saunders, Chloë E. George, Thomas G. Scorer, Lynn M. R. McCallum, Tracey E. Madgett   +5 more
wiley   +1 more source

Long‐term forecasting of blood donations using time series of donation activity: Findings from seven blood establishments

Vox Sanguinis, EarlyView.
Abstract Background and Objectives To meet the long‐term demand for blood products while preserving donor health in the long run, blood establishments must recruit a sufficient number of new donors annually. To determine what will suffice, it is essential to be able to forecast future blood donation volumes as a function of new donors using estimates ...
Timo Asikainen, Tinus Brits, Ronél Swanevelder, Jose Antonio García Erce, Lucile Malard, Iris Garcia‐Martínez, Marijke Welvaert, Surendra Karki, Tea Lallukka, Mart Pothast, Mikko Arvas   +10 more
wiley   +1 more source

The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2

Viruses
Bone marrow stromal cell antigen 2 (BST-2) is a restriction factor for human immunodeficiency virus type I (HIV-1) and plays an important role in regulating the release of viral particles.
Man-Di Zhang, Fan Chen, Wen-Qiang He, Ying Lu, Feng-Liang Liu, Hong-Guang Zhang, Liu-Meng Yang, Chun-Sheng Dong, Si-Dong Xiong, Yong-Tang Zheng   +9 more
doaj   +1 more source

The value of segmenting the milk market into bST-Produced and Non-bST-Produced milk [PDF]

Agribusiness, 1994
This article discusses the value to milk producers and consumers of segmenting the milk market into bovine Somatotropin- (bST) produced milk and non-bST-produced milk markets, versus losing milk consumption from consumers who will not consume bST-produced milk.
openaire   +2 more sources