Results 161 to 170 of about 6,331 (185)

BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface [PDF]

Virology, 2014
Bone marrow stromal antigen 2 (BST2), an interferon-inducible antiviral factor, has been shown to block the release of various enveloped viruses from cells. It has also been identified as an innate immune system component.
Chin-Tien Wang
exaly   +2 more sources

BST2 inhibits infection of influenza A virus by promoting apoptosis of infected cells

Biochemical and Biophysical Research Communications, 2019
BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells. Influenza-infected BST2-deficient
Se-Ho Park, Moon Jung Song, Hye-Ri Kang   +2 more
exaly   +3 more sources

Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E [PDF]

Virology, 2017
It has been well documented that BST2 restricts the release of enveloped viruses by cross-linking newly produced virions to the cell membrane. However, it is less clear whether and how BST2 inhibits the release of enveloped viruses which bud via the ...
Gengfu Xiao, Qinxue Hu
exaly   +2 more sources

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IFN-γ-induced BST2 mediates monocyte adhesion to human endothelial cells

Cellular Immunology, 2011
BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs.
Sang-Kyu Ye
exaly   +3 more sources

Identification of BST2 as a biomarker for alopecia areata in both mice and humans

The Journal of Immunology, 2023
Abstract Alopecia areata is an autoimmune disease characterized by aberrant non-scarring hair loss. 147 million people worldwide are currently diagnosed with alopecia areata with a lifetime incidence of 2.1%. The hair follicle is a site of immune privilege however in alopecia areata, CD4+ helper T cells and CD8+ cytotoxic T cells ...
Cristina Velasquez, Jake Coast
openaire   +1 more source

BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1

Molecular Carcinogenesis
AbstractGastric cancer (GC) constitutes substantial cancer mortality worldwide. Several cancer types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9 ...
Jide Wang, Jiaying Li
exaly   +3 more sources

BST2 Promotes Tumor Growth via Multiple Pathways in Hepatocellular Carcinoma

Cancer Investigation, 2020
Bone marrow stromal antigen 2 (BST2) is a transmembrane glycoprotein and plays an essential role in innate immunity. Here we firstly found that BST2 expression was significantly elevated in hepatocellular carcinoma (HCC) tissues. High BST2 was closely related to the larger tumor size and more tumor number.
Xiaoguang, Xu, Yu, Wang, Fangxi, Xue, Encui, Guan, Feng, Tian, Jian, Xu, Hongjin, Zhang   +6 more
exaly   +3 more sources

Membrane flexibility induced by BST2 contributes to radioresistance in glioblastoma

Oncogene
Glioblastoma (GBM) is an aggressive brain tumor with a poor prognosis due to its resistance to radiotherapy. Epidermal growth factor receptor variant III (EGFRvIII), a common mutation in GBM, promotes radioresistance through ligand-independent activation.
Haksoo Lee, Dahye Kim, Byeongsoo Kim, Eunguk Shin, Hyunkoo Kang, Jae-Myung Lee, HyeSook Youn, BuHyun Youn   +7 more
openaire   +2 more sources

Generation and initial characterization of in vivo knockout of tetherin/BST2 in chicken

ABSTRACT Tetherin/BST2 is an antiviral restriction factor initially described in mammals. It is active against multiple enveloped viruses at the budding phase, where it is able to physically link the budding virions to the virus-producing cell.
Lenka Ungrová, Pavel Trefil, Jiří Plachý, Jitka Mucksová, Jiří Kalina, Markéta Reinišová, Sonja Härtle, Eliška Gáliková, Dana Kučerová, Veronika Krchlíková, Vladimír Pečenka, Vít Karafiát, Jiří Hejnar, Daniel Elleder   +13 more
openaire   +1 more source

Autophagy‐related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2

Journal of Medical Virology
AbstractHepatitis B virus (HBV) infection is a major global health burden with 820 000 deaths per year. In our previous study, we found that the knockdown of autophagy‐related protein 5 (ATG5) significantly upregulated the interferon‐stimulated genes (ISGs) expression to exert the anti‐HCV effect.
Qingyuan Li, Wenxian Wen, Yijin Wang, Tao Gong, Xinwei Wang, Qi Tan, Bin Fan, He Xie, Yujia Li, Shilin Li, Chunhui Yang, Zhonghui Zhou, Xiaoqiong Duan, Wenyu Lin, Limin Chen   +14 more
openaire   +2 more sources