Identification of key genes associated with endometriosis and endometrial cancer by bioinformatics analysis. [PDF]
Front OncolMa R +7 more
europepmc +1 more source
Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis. [PDF]
Front Mol BiosciLiu X +10 more
europepmc +1 more source
Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker
Identification of BST2 as a conjunctival epithelial stem/progenitor cell markeropenaire
Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E [PDF]
Virology, 2017 It has been well documented that BST2 restricts the release of enveloped viruses by cross-linking newly produced virions to the cell membrane. However, it is less clear whether and how BST2 inhibits the release of enveloped viruses which bud via the ...
Ping Wang, Kai Hu, Mudan Zhang
exaly +5 more sources
ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway
Proceedings of the National Academy of Sciences of the United States of America, 2023 Bone marrow stromal antigen 2 (BST2)/tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virus at the cell surface. BST2 also acts as a sensor of HIV-1 budding, establishing a cellular antiviral state. The HIV-1 Vpu protein antagonizes BST2 antiviral functions via multiple mechanisms, including the subversion of an LC3C ...
Delphine Judith +2 more
exaly +3 more sources
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Murine BST2/tetherin promotes measles virus infection of neurons
Virology, 2021BST2/tetherin is a transmembrane protein with antiviral activity; it is synthesized following exposure to interferons, and restricts the release of budding virus particles by tethering them to the host cell membrane. We previously showed that BST2 is induced in primary neurons following measles virus (MV) infection or type I interferon; however, BST2 ...
Christine Matullo +2 more
exaly +3 more sources
Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2
Cell Reports, 2020 During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined.
Katherine Y King +2 more
exaly +4 more sources
IFN-γ-induced BST2 mediates monocyte adhesion to human endothelial cells
Cellular Immunology, 2011BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs.
Sang-Kyu Ye
exaly +3 more sources
The expression of BST2 in human and experimental mouse brain tumors [PDF]
Experimental and Molecular Pathology, 2011 Glioblastoma multiforme (grade IV astrocytoma) is a highly malignant brain tumor with poor treatment options and an average lifespan of 15 months after diagnosis. Previous work has demonstrated that BST2 (bone marrow stromal cell antigen 2; also known as PDCA-1, CD137 and HM1.24) is expressed by multiple myeloma, endometrial cancer and primary lung ...
Derek A Wainwright
exaly +3 more sources
Stimulation of NF-κB Activity by the HIV Restriction Factor BST2 [PDF]
Journal of Virology, 2013 ABSTRACT BST2 (HM1.24; CD317; tetherin) is an interferon-inducible transmembrane protein that restricts the release of several enveloped viruses, including HIV, from infected cells. Before its activity as an antiviral factor was described, BST2 was identified as an inducer of NF-κB activity.
Rajendra Singh, John Guatelli
exaly +3 more sources