Results 171 to 180 of about 8,611 (185)
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BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells
Antiviral Research, 2013Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently treated with alpha interferon (IFN-α)-based therapies. IFN-induced cell membrane protein BST2 (also known as CD317, HM1.24 or tetherin) has been reported to tether a broad range of lipid-enveloped viruses on cell surfaces. However, whether HCV is sensitive to BST2
Xiao-Ben Pan, Xiao-Wang Qu
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BST2 Promotes Tumor Growth via Multiple Pathways in Hepatocellular Carcinoma
Cancer Investigation, 2020Bone marrow stromal antigen 2 (BST2) is a transmembrane glycoprotein and plays an essential role in innate immunity. Here we firstly found that BST2 expression was significantly elevated in hepatocellular carcinoma (HCC) tissues. High BST2 was closely related to the larger tumor size and more tumor number.
Xiaoguang, Xu +6 more
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BST2 inhibits infection of influenza A virus by promoting apoptosis of infected cells
Biochemical and Biophysical Research Communications, 2019 BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells. Influenza-infected BST2-deficient
Moon Jung Song, Se-Ho Park
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BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer
Biotechnology Letters, 2018To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis ...
Weiyu Liu, Changqing Zheng
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BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1
Molecular CarcinogenesisAbstractGastric cancer (GC) constitutes substantial cancer mortality worldwide. Several cancer types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9 ...
Jide Wang, Jiaying Li
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Journal of Medical Virology
AbstractHepatitis B virus (HBV) infection is a major global health burden with 820 000 deaths per year. In our previous study, we found that the knockdown of autophagy‐related protein 5 (ATG5) significantly upregulated the interferon‐stimulated genes (ISGs) expression to exert the anti‐HCV effect.
Qingyuan Li +14 more
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AbstractHepatitis B virus (HBV) infection is a major global health burden with 820 000 deaths per year. In our previous study, we found that the knockdown of autophagy‐related protein 5 (ATG5) significantly upregulated the interferon‐stimulated genes (ISGs) expression to exert the anti‐HCV effect.
Qingyuan Li +14 more
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AbstractBackgroundSmooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases, but their role in tumorigenesis is unknown. We investigated whether and how SMC diversity and plasticity plays a role in tumor angiogenesis and the tumor microenvironment.Methods and ResultsWe use SMC-specific ...
Caitlin F. Bell +12 more
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Caitlin F. Bell +12 more
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