Results 151 to 160 of about 80,266 (330)

Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors

Blood Advances, 2023
Jialei Qi, Sascha Endres, Deyan Yordanov Yosifov, Eugen Tausch, Rashmi Priyadharshini Dheenadayalan, Xiang Gao, Annika Müller, Christof Schneider, Daniel Mertens, Peter Gierschik, Martin Wist, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer   +12 more
openaire   +2 more sources

Multi‐omics profiling of chronic immune‐mediated skin diseases: SKINERGY protocol and strategic evaluation

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The SKINERGY study will investigate six immune‐mediated inflammatory skin diseases through a nationwide collaboration across all Dutch university medical centres. Involving 720 patients and 120 healthy volunteers, it is aimed at generating a high‐quality dataset to identify biomarkers that enable personalized treatment strategies and improved disease ...
N. G. Koster, J. M. P. A. van den Reek, E. M. G. J. de Jong, S. van Beugen, A. I. M. van Laarhoven, I. Haeck, M. de Bruin‐Weller, M. L. Schuttelaar, B. Horvath, A. Gostyński, A. Knulst, M. H. Vermeer, L. Nguyen, L. Gerbens, P. Spuls, M. A. Middelkamp‐Hup, V. Exadaktylos, T. Niemeyer‐van der Kolk, A. R. Schrader, A. M. Sluijmers, J. Versteeg, B. W. M. Arents, I. van Ee, J. L. A. G. van der Zon, M. de Leeuw, T. de Leeuw, P. van den Broek, C. Berkhof, D. Vellinga, S. Weidinger, S. Dubrac, Y. Li, M. van Steensel, M. Marchetti‐Deschmann, M. Maurer, H. van der Zee, J. Damman, D. J. Hijnen, F. Wijk, M. M. B. Seyger, H. Röckmann, D. M. W. Balak, M. B. A. van Doorn, R. Rissmann, The Next Generation ImmunoDermatology (NGID) consortium, Rob Vreeken, Eva Cuypers, Boudewijn Lelieveldt, Abdoel El Ghalbzouri, Hanna Niehues, Ellen van den Bogaard, Tom Ederveen, Els van der Pool, Nanda Olde, Debra Trampe, Ellen Stijl‐’t Hart, Lisanne Wezendonk, Johan Westerhuis, Huma Shehwana, Joerg Schreiber, Jeremy Bost, Mie Bech Lukassen, Jimmy Bakker, Juliette Simons, Fauve van den Berge, Colin Spence, Elise Beljaards, Anastasiia Myronenko, Mariona Oliver   +68 more
wiley   +1 more source

Innovation Diffusion Among Case‐Based Decision‐Makers

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT This paper analyzes a model of innovation diffusion with case‐based individuals a la Gilboa and Schmeidler, who decide whether to consume an incumbent or a new product based on their and their social neighbors' previous consumption experiences. I analyze how diffusion patterns change with individual characteristics, innovation characteristics,
Benson Tsz Kin Leung
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core.
David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti   +5 more
doaj   +1 more source

Point-contact Andreev-reflection spectroscopy in segregation-free Mg_{1-x}Al_{x}B_2 single crystals up to x=0.32

, 2008
We present new results of point-contact Andreev-reflection (PCAR) spectroscopy in single-phase Mg_{1-x}Al_{x}B_{2} single crystals with x up to 0.32. Fitting the conductance curves of our point contacts with the two-band Blonder-Tinkham-Klapwijk model ...
Calzolari, A., Daghero, D., Delaude, D., Gonnelli, R. S., Karpinski, J., Katrych, S, Stepanov, V. A., Tortello, M., Ummarino, G. A., Zhigadlo, N. D.   +9 more
core   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Towards a Microscopic Theory for Metallic Heavy-Fermion Point Contacts

, 1996
The bias-dependent resistance R(V) of NS-junctions is calculated using the Keldysh formalism in all orders of the transfer matrix element. We present a compact and simple formula for the Andreev current, that results from the coupling of electrons and ...
Blonder, Caroli, Caroli, Cox, De Wilde, F.B. Anders, Gloos, Goll, K. Gloos, Naidyuk, Nowack, Schrieffer   +11 more
core   +1 more source

Cardiovascular Toxicities of BTK Inhibitors in Chronic Lymphocytic Leukemia

JACC CardioOncology, 2023
Cooper J. Quartermaine, S. Ghazi, Aneeq Yasin, F. Awan, M. Fradley, Tracy E. Wiczer, Sujay Kalathoor, M. Ferdousi, Satyam Krishan, Alma Habib, Adnan Shaaban, Onaopepo Kola-Kehinde, A. Kittai, K. Rogers, M. Grever, P. Ruz, S. Bhat, Tyler Dickerson, John C. Byrd, J. Woyach, Daniel Addison   +20 more
semanticscholar   +1 more source

Targetable Vulnerabilities in MYC‐Driven B Cell Lymphomas Resistant to BCR Extinction

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT Polatuzumab vedotin, an antibody‐drug conjugate (ADC) targeting the B cell receptor (BCR) signaling subunit CD79B, has recently entered frontline therapy for diffuse large B cell lymphoma (DLBCL) and high‐grade B cell lymphoma (HGBCL), achieving encouraging clinical results. However, MYC‐driven B cell lymphomas, particularly HGBCL with MYC and
Silvia Brambillasca, Nicara Chantal Parr, Adriana Palmeri, Adrian Andronache, Hiroshi Arima, Giovanni Faga’, Brian Leuzzi, Laura Perucho, Michela Robusto, Maurizio Pasi, Federica Mainoldi, Daniele Fancelli, Mario Varasi, Gabriele Varano, Ciro Mercurio, Stefano Casola   +15 more
wiley   +1 more source