Results 41 to 50 of about 80,266 (330)
The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View
Journal of Experimental Pharmacology, 2021 Francesco Paolo Tambaro,1 Danilo De Novellis,1,2 William G Wierda3 1Unità Operativa di Trapianto di Midollo Osseo e Servizio Trasfusionale, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italy; 2Department of Precision Medicine ...
Tambaro FP, De Novellis D, Wierda WG
doaj
Phylloplane Sterilization With Bleach Does Not Reduce Btk Toxicity for \u3ci\u3ePapilio Glaucus\u3c/i\u3e Larvae (Lepidoptera: Papilionidae) [PDF]
, 2018 Neonate tiger swallowtail larvae (Papilio glaucus) were used to bioassay the effects of Btk (Bacillus thuringiensis var. kurstaki) at 4 doses (0.268, 0.034, 0.008, and 0.004 BIU per cm leaf surface) with an untreated control.
Haas, Laura, Scriber, J. Mark
core +2 more sources
Blood Advances, 2022 Key Points • BCR signaling is inhibited by pirtobrutinib in vitro and in vivo regardless of BTK C481S mutation but is reactivated in vivo at progression.• BTK mutations at the gatekeeper site T474 and second-site kinase-dead mutations lead to resistance ...
A. Naeem +24 more
semanticscholar +1 more source
Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. [PDF]
PLoS Pathogens, 2013 Phagocytosis of the opportunistic fungal pathogen Candida albicans by cells of the innate immune system is vital to prevent infection. Dectin-1 is the major phagocytic receptor involved in anti-fungal immunity. We identify two new interacting proteins of
Karin Strijbis +11 more
doaj +1 more source
Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia.
New England Journal of Medicine, 2022 BACKGROUND Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means of dual mechanisms of action: decreased macrophage (Fcγ receptor)-mediated ...
D. Kuter +28 more
semanticscholar +1 more source
Kvantitatív drámaelemzés és az idő
Digitális Bölcsészet, 2023 A kvantitatív drámaelemzés legtöbbször a színművek egészére vonatkozó, statikus mérőszámokból indul ki, továbbá kevés figyelmet fordít az e mérőszámokkal leírt szerkezeti tulajdonságok történeti változásaira. A tanulmányban ezért korábbi eredményeinket,
Botond Szemes, Magyar Magyar
doaj +1 more source
Pharmaceuticals, 2023 Bruton’s tyrosine kinase (BTK) is a critical component in B-cell receptor (BCR) signaling and is also expressed in haematogenic and innate immune cells. Inhibition of BTK hyperactivity is implicated in B-cell malignancies and autoimmune diseases.
Asim Najmi +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged behind development of these drugs for treating cancers, due in part from concerns over the lack of selectivity and associated toxicity profiles of first generation ...
G. Ringheim, M. Wampole, Kinsi Oberoi
semanticscholar +1 more source
Bruton’s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response
Cell Death and Disease, 2021 Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the
Di Guan +4 more
doaj +1 more source
Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies
Frontiers in Cell and Developmental Biology, 2021 Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR).
Stefan F. H. Neys +2 more
doaj +1 more source