Results 61 to 70 of about 80,266 (330)

A vajdasági/délvidéki magyarok nemzeti identitása 1990-től napjainkig – II.

Metszetek, 2019
Tanulmányunk második részében bemutatjuk a vajdasági/délvidéki magyarok harmadik generációjának, az 1990 után színre lépettek nemzeti identitásának politikai-állampolgári és kulturális-történeti összetevőinek átalakulási folyamatait.
Teréz Kovács, Igor Kiss
doaj   +1 more source

A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications

Molecules, 2023
Bruton tyrosine kinase (BTK) is an essential enzyme in the signaling pathway of the B-cell receptor (BCR) and is vital for the growth and activation of B-cells.
Qi Zhang, Changming Wen, Lijie Zhao, Yatao Wang   +3 more
doaj   +1 more source

Interaction between the Btk PH Domain and Phosphatidylinositol-3,4,5-trisphosphate Directly Regulates Btk [PDF]

Journal of Biological Chemistry, 2001
Bruton's tyrosine kinase (Btk) binds to phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P(3)) through the Btk pleckstrin homology (PH) domain, an interaction thought to be required for Btk membrane translocation during B cell receptor signaling. Here, we report that interaction of PtdIns-3,4,5-P(3) with the PH domain of Btk directly induces Btk ...
K, Saito, A M, Scharenberg, J P, Kinet
openaire   +2 more sources

Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer [PDF]

, 2004
X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, near absence of serum immunoglobulin, and recurrent bacteria infections.
Astrakhan, A., Chae, K., Ellmeier, W., Humblet, Stéphanie, Kato, R. M., Kipp, K., Rawlings, D. J., Tabuchi, R. S., Witte, O. N., Yu, P. W.   +9 more
core   +1 more source

Inverting the BTK-BCL2 order [PDF]

Blood, 2020
In this issue of Blood, Lin et al report the first long-term follow-up data showing that Bruton tyrosine kinase inhibitors (BTKi's) are effective in chronic lymphocytic leukemia (CLL) after previous progression on venetoclax.
openaire   +2 more sources

Targeting BTK in B Cell Malignancies: From Mode of Action to Resistance Mechanisms

International Journal of Molecular Sciences
The B cell receptor (BCR) signaling pathway plays a crucial role in B cell development and contributes to the pathogenesis of B cell neoplasms. In B cell malignancies, the BCR is constitutively active through both ligand-dependent and ligand-independent ...
S. Mouhssine, Nawar Maher, B. Matti, A. Alwan, Gianluca Gaidano   +4 more
semanticscholar   +1 more source

The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients

Blood, 2020
Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness.
S. Treon, J. Castillo, A. Skarbnik, J. Soumerai, I. Ghobrial, M. Guerrera, K. Meid, Guang Yang   +7 more
semanticscholar   +1 more source

Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial

Clinical and Translational Science, 2021
Safe and effective new oral therapies for autoimmune, allergic, and inflammatory conditions remain a significant therapeutic need. Here, we investigate the human pharmacokinetics, pharmacodynamics (PDs), and safety of the selective, covalent Bruton’s ...
M. Kaul, P. End, M. Cabański, Carole Schuhler, A. Jakab, M. Kistowska, A. Kinhikar, Alessio Maiolica, Angela Sinn, R. Fuhr, B. Cenni   +10 more
semanticscholar   +1 more source

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

Investigation of the superconducting energy gap in the compound LuNi$_{2}$B$_{2}$C by the method of point contact spectroscopy: two-gap approximation [PDF]

, 2005
It is shown that the two-gap approximation is applicable for describing the $dV/dI(V)$ spectra of LuNi$_{2}$B$_{2}$C-Ag point contacts in a wide interval of temperatures.
Beloborod'ko, S. I., Bobrov, N. L., Chernobay, V. N., Naugle, D. G., Rathnayaka, K. D. D., Tyutrina, L. V., Yanson, I. K.   +6 more
core   +2 more sources