An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems [PDF]
Pharmaceutics, 2021 Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in ...
Shery Jacob +5 more
doaj +3 more sources
Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin [PDF]
Pharmaceutics, 2021 Buccal drug delivery is a suitable alternative to invasive routes of drug administration. The buccal administration of insulin for the management of diabetes has received substantial attention worldwide.
Santosh Bashyal +5 more
doaj +3 more sources
Factors affecting the buccal delivery of deformable nanovesicles based on insulin–phospholipid complex: an in vivo investigation [PDF]
Drug Delivery, 2020 Deformable nanovesicles (DNVs) have been used in the buccal delivery of biomacromolecules due to their ability to enhance drug penetration. However, no breakthroughs have been made until now due to limited understanding of the factors affecting in vivo ...
Yuqi Yang +6 more
doaj +3 more sources
Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal Delivery System [PDF]
Pharmaceutics, 2022 Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously proven to be a
Hassa A. Alshaya +13 more
doaj +3 more sources
Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins [PDF]
Pharmaceuticals, 2020 Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing.
Georgios Eleftheriadis +7 more
doaj +3 more sources
Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery [PDF]
Frontiers in Pharmacology, 2019 Oral route maintains its predominance among the ones used for drug delivery, especially when medicines are self-administered. If the dosage form is solid, therapy gains in dose precision and drug stability.
Renata Carvalho Feitosa +7 more
doaj +3 more sources
Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin [PDF]
International Journal of Nanomedicine, 2018 You Xu,1,2 Xing Zhang,1,2 Yun Zhang,1,2 Jun Ye,1,2 Hong-Liang Wang,1,2 Xuejun Xia,1,2 Yuling Liu1,2 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & ...
Xu Y +6 more
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Development and Characterization of Chitosan Microparticles-in-Films for Buccal Delivery of Bioactive Peptides [PDF]
Pharmaceuticals, 2019 Nowadays, bioactive peptides are used for therapeutic applications and the selection of a carrier to deliver them is very important to increase the efficiency, absorption, release, bioavailability and consumer acceptance.
Patrícia Batista +4 more
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Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation. [PDF]
Polymers (Basel), 2022 Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF.
Aldawsari MF +3 more
europepmc +2 more sources
High-Payload Buccal Delivery System of Amorphous Curcumin-Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films. [PDF]
Int J Mol Sci, 2021 Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility.
Lim LM, Hadinoto K.
europepmc +2 more sources