Results 31 to 40 of about 1,353,755 (237)

CURRENT STATUS OF BUCCAL DRUG DELIVERY SYSTEM: A REVIEW [PDF]

, 2015
Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. The buccal region of the oral cavity is an attractive target for administration of the drug of choice ...
Monga, Munish Garg, Srivastava, Namita
core   +1 more source

Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation

International Journal of Nanomedicine, 2021
Santosh Bashyal,1 Jo-Eun Seo,1 Taekwang Keum,1,2 Gyubin Noh,1,2 Shrawani Lamichhane,1,2 Jeong Hwan Kim,1,2 Chang Hyun Kim,3 Young Wook Choi,3 Sangkil Lee1,2 1College of Pharmacy, Keimyung University, Daegu, Republic of Korea; 2Center for Forensic ...
Bashyal S, Seo JE, Keum T, Noh G, Lamichhane S, Kim JH, Kim CH, Choi YW, Lee S   +8 more
doaj  

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery

Gels, 2022
Carvedilol (CRV) is a non-selective third generation beta-blocker used to treat hypertension, congestive heart failure and angina pectoris. Oral administration of CRV showed poor bioavailability (25%), which might be ascribed to its extensive first-pass ...
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad   +13 more
doaj   +1 more source

Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies

Saudi Pharmaceutical Journal, 2014
Delivery of orally compromised therapeutic drug molecules to the systemic circulation via buccal route has gained a significant interest in recent past.
A. Jaipal, M.M. Pandey, S.Y. Charde, P.P. Raut, K.V. Prasanth, R.G. Prasad   +5 more
doaj   +1 more source

Interpolymer Complexes Based on Carbopol^® and Poly(2-ethyl-2-oxazoline) as Carriers for Buccal Delivery of Metformin

Разработка и регистрация лекарственных средств, 2021
Introduction. Buccal drug delivery has a number of advantages over oral administration: ease of application, good blood supply to the buccal mucosa, drug can enter the systemic circulation directly, avoiding the "first pass effect through the liver", and
A. S. Viktorova, E. S. Elizarova, R. S. Romanova, V. R. Timergalieva, V. V. Khutoryanskiy, R. I. Moustafine   +5 more
doaj   +1 more source

Formulation and Evaluation of Biopolymer Based Buccal Film of Diclofenac Sodium

Journal of Basic and Applied Research in Biomedicine, 2022
Buccal drug delivery gives easier and safe method of drug administration because in case of toxicity it can be terminated by simply removing the dosage form from buccal cavity.
Pooja Kashid, Amit Jadhav, Nagesh Aloorkar   +2 more
doaj   +2 more sources

Deformable Nanovesicle-Loaded Gel for Buccal Insulin Delivery

Pharmaceutics, 2022
Deformable nanovesicles (DNVs) have been widely used in oral mucosal delivery studies of biomolecular drugs. However, their development for oral mucosal preparations has been limited by their physical and chemical instability, the need for small oral ...
Yiyue Guo, Yuqi Yang, You Xu, Yingying Meng, Jun Ye, Xuejun Xia, Yuling Liu   +6 more
doaj   +1 more source

Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration

Frontiers in Pharmacology, 2019
The sublingual and buccal routes of administration have significant advantages for both local and systemic drug delivery. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required ...
Susan Hua, Susan Hua
doaj   +1 more source

Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs

Pharmaceutics, 2023
Injectable peptides such as insulin, glucagon-like peptide 1 (GLP-1), and their agonists are being increasingly used for the treatment of diabetes. Currently, the most common route of administration is injection, which is linked to patient discomfort as ...
Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli, Anika Singh   +3 more
doaj   +1 more source

Advancements in Buccal Drug Delivery: Polymers and Their Applications

RGUHS Journal of Pharmaceutical Sciences
Buccal drug delivery offers a promising alternative to conventional oral routes by facilitating the rapid and efficient absorption of therapeutics directly through the mucosal tissues lining the oral cavity.
Shardor Ambarish G, Siddramappa B Shirsand, Anand Kumar Yegnoor   +2 more
doaj   +1 more source