Results 1 to 10 of about 16,561,111 (163)

Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes [PDF]

International Journal of Nanomedicine, 2018
Santosh Bashyal,1 Jo-Eun Seo,1 Taekwang Keum,1 Gyubin Noh,1 Young Wook Choi,2 Sangkil Lee1 1College of Pharmacy, Keimyung University, Daegu, Republic of Korea; 2College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea Background: Buccal ...
Bashyal S, Seo JE, Keum T, Noh G, Choi YW, Lee S   +5 more
doaj   +7 more sources

In Vitro and Ex Vivo Evaluation of Penetratin as a Non-invasive Permeation Enhancer in the Penetration of Salmon Calcitonin through TR146 Buccal Cells and Porcine Buccal Tissues [PDF]

Pharmaceuticals, 2020
Buccal tissues are considered one of the potential alternative delivery route because of fast drug absorption and onset of action due to high vascularization and a non-keratinized epithelial membrane.
Taekwang Keum, Gyubin Noh, Jo-Eun Seo, Santosh Bashyal, Sangkil Lee   +4 more
doaj   +7 more sources

The Anti-Inflammatory Effects of Iberin on TNF-α-Stimulated Human Oral Epithelial Cells: In Vitro Research

Biomedicines, 2022
Iberin is a bioactive chemical found in cruciferous plants that has been demonstrated to have anticancer properties. However, there have been no reports on its effects on periodontal resident cells, and many questions remain unanswered.
Yoshitaka Hosokawa, Ikuko Hosokawa, Masahiro Shimoyama, Ayumi Fujii, Juri Sato, Kimitake Kadena, Kazumi Ozaki, Keiichi Hosaka   +7 more
doaj   +3 more sources

Development of a tissue-engineered oral mucosal barrier model using poly (l-lactic acid) electrospun nanofibers [PDF]

Scientific Reports
The oral mucosa is a crucial barrier that defends against external factors and regulates tissue permeability. To advance trans-epithelial drug delivery and dental biomaterials research, a robust in vitro model of oral mucosal tissue is needed. This study
Andari Sarasati, Deniz Yucel, Halime Kenar, Hevi Wihadmadyatami, Neval Sevinc Ozdemir, Rahmi Anggraeni, Vasif Hasirci, Ika Dewi Ana   +7 more
doaj   +3 more sources

Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity [PDF]

Scientific Reports
Periodontitis is a chronic gum disease characterised by inflammation and the loss of bone. We have explored the potential prophylactic effects of lysates from four Lactobacillus strains against the toxic effects of three periodontal pathogens ...
Steven D. Mercer, Christopher Doherty, Gurdeep Singh, Thomas Willmott, Tanaporn Cheesapcharoen, Rawee Teanpaisan, Catherine O’Neill, Ruth G. Ledder, Andrew J. McBain   +8 more
doaj   +3 more sources

Investigation of Cytotoxicity, Permeability, and Stability of Captopril-Loaded Chitosan-Ascorbate Buccal Films [PDF]

Pharmaceuticals
Background: Buccal films have attracted continued interest due to their several advantages. However, developing effective buccal films for hydrophilic drugs remains challenging due to limited buccal permeability.
Hala Rayya, Raghad Alsheikh, Dániel Nemes, Lajos Nagy, Géza Regdon, Ildikó Bácskay, Katalin Kristó, Krisztián Pamlényi   +7 more
doaj   +3 more sources

6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells

Current Issues in Molecular Biology, 2022
6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects.
Masahiro Shimoyama, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Keiichi Hosaka   +4 more
doaj   +2 more sources

Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro

Pathogens, 2023
The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there is limited evidence of active oral infection by SARS-CoV-2 viruses. We assessed the capacity of SARS-CoV-2 to infect and replicate in oral epithelial cells.
Laith Ebraham, Chuan Xu, Annie Wang, Cyril Hernandez, Nicholas Siclari, Divino Rajah, Lewins Walter, Salvatore A. E. Marras, Sanjay Tyagi, Daniel H. Fine, Carlo Amorin Daep, Theresa L. Chang   +11 more
doaj   +2 more sources

In Vitro and Ex Vivo Studies on the Absorption and Distribution of β-Cyclodextrin Polymer [PDF]

Pharmaceutics
Background: Cyclodextrin (CD) polymers have attracted increasing attention due to their favourable drug delivery properties and broad pharmaceutical applicability.
Réka Révész, Akay Dogan Mengenli, Ágnes Rusznyák, Richárd Kajtár, István Lekli, Ildikó Bácskay, Ádám Haimhoffer   +6 more
doaj   +2 more sources

Formulation and Characterization of Captopril-Loaded Chitosan Mucoadhesive Buccal Films with Different Permeation-Enhancing Components [PDF]

Pharmaceutics
Background/Objectives: The buccal mucosa offers a promising non-invasive route for systemic drug delivery, particularly for hydrophilic compounds like captopril (CAP), which exhibit low permeability and are subject to gastrointestinal instability and ...
Hala Rayya, Raghad Alsheikh, Dániel Nemes, Lajos Nagy, Géza Regdon, Ildikó Bácskay, Krisztián Pamlényi, Katalin Kristó   +7 more
doaj   +2 more sources