Results 11 to 20 of about 16,561,111 (163)

IL-27 Modulates Chemokine Production in TNF-α -Stimulated Human Oral Epithelial Cells [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Interleukin-27 (IL-27) is a cytokine which belongs to the IL-12 family. However, the role of IL-27 in the pathogenesis of periodontal disease is uncertain.
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo   +3 more
doaj   +5 more sources

Human Oral Epithelial Cells Impair Bacteria-Mediated Maturation of Dendritic Cells and Render T Cells Unresponsive to Stimulation

Frontiers in Immunology, 2019
The oral mucosa is a first line of defense against pathogenic organisms and yet tolerates food antigens and resident bacteria. Mucosal epithelial cells are emerging as important regulators of innate and adaptive immune responses.
Magdalena Molero-Abraham, Jose L. Sanchez-Trincado, Marta Gomez-Perosanz, Alvaro Torres-Gomez, Jose Luis Subiza, Esther M. Lafuente, Pedro A. Reche   +6 more
doaj   +3 more sources

Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes [PDF]

Mucosal Immunology, 2009
Expressed by squamous mucosal keratinocytes, calprotectin is a complex of two EF-hand calcium-binding proteins of the S100 subfamily (S100A8 and S100A9) with significant antimicrobial activity. Calprotectin-expressing cells resist invasion by Porphyromonas gingivalis, Listeria monocytogenes, and Salmonella enterica serovar Typhimurium (S. typhimurium).
Aa Zaia, KJ Sappington, K. Nisapakultorn, WJ Chazin, EA Dietrich, KF Ross, M. Herzberg   +6 more
semanticscholar   +4 more sources

Molecular weight-dependent hyaluronic acid permeability and tight junction modulation in human buccal TR146 cell monolayers.

International Journal of Biological Macromolecules, 2022
The oral route is considered an attractive method for drug delivery, as it avoids the hepatic and intestinal first-pass metabolism processes. Hyaluronic acid (HA) beneficial effects to the human body include anti-aging and wound healing but its effects ...
Ha-Young Park, D. Kweon, Jae-Kyung Kim
semanticscholar   +3 more sources

Human TR146 cells and pig buccal mucosa to assess oral transmucosal passage and buccal toxicity of foodgrade titanium dioxide

, 2022
Background: Today, the use of titanium dioxide (TiO 2) as food additive (E171) has been banned by the European Commission, due to concerns for human health based on studies showing TiO 2 particles systematically available, tissue accumulation, a genotoxic risk and possible promotion of precancerous lesions. However, E171 is still present in toothpastes
Vignard, Julien, Pettes-Duler, Aurélie, Gaultier, Eric, Cartier, Christel, Weingarten, Laurent, Biesemeier, A., Pinton, Philippe, Bebeacua, C., Devoille, Laurent, Dupuy, Jacques, Boutet-Robinet, Elisa, Feltin, Nicolas, Oswald, Isabelle P., Pierre, Fabrice H.F., Lamas, Bruno, Mirey, Gladys, Houdeau, Eric   +16 more
core   +5 more sources

Human Oral Epithelial Cells Suppress T Cell Function via Prostaglandin E2 Secretion

Frontiers in Immunology, 2022
The oral mucosa is constantly exposed to a plethora of stimuli including food antigens, commensal microbiota and pathogens, requiring distinct immune responses.
Jose L. Sanchez-Trincado, Hector F. Pelaez-Prestel, Esther M. Lafuente, Pedro A. Reche   +3 more
doaj   +2 more sources

Optimization of an oral mucosa in vitro model based on cell line TR146 [PDF]

Tissue Barriers, 2020
During the last years, the popularity of saliva has been increasing for its applicability as a diagnostic fluid. Blood biomarker molecules have to cross the blood-saliva barrier (BSB) in order to appear in saliva. The BSB consists of all oral and salivary gland epithelial barriers.
Lin, Grace C., Leitgeb, Tamara, Vladetic, Alexandra, Friedl, Heinz-Peter, Rhodes, Nadine, Rossi, Angela, Roblegg, Eva, Neuhaus, Winfried   +7 more
openaire   +3 more sources

Expression of S100A8 is induced by interleukin‑1α in TR146 epithelial cells through a mechanism involving CCAAT/enhancer binding protein β.

Molecular Medicine Reports, 2019
Calprotectin in mucosal epidermal keratinocytes has an important role in fighting microbial infections. S100A8 belongs to the S100 protein family and is a subunit of calprotectin (heterodimer complex of S100A8/A9).
Mingqun Qin, Yantao Zou, Kanghua Zhong, Yong Guo, Xian-Qiong Zou   +4 more
semanticscholar   +4 more sources

Acid Dentin Lysates Increase Amelotin Expression in Oral Epithelial Cells and Gingival Fibroblasts

Applied Sciences, 2021
Amelotin (AMTN) is a secretory calcium-binding phosphoprotein controlling the adhesion of epithelial cells to the tooth surface, forming a protective seal against the oral cavity.
Jila Nasirzade, Zahra Kargarpour, Layla Panahipour, Reinhard Gruber   +3 more
doaj   +2 more sources

Boosting buccal drug absorption: Mechanistic insights into bilosome-mediated delivery [PDF]

International Journal of Pharmaceutics: X
Effective buccal drug delivery is limited by the barrier properties of the mucosa, necessitating innovative systems to enhance permeability without compromising tissue integrity.
Eleftheria Pantazoglou, Scarlett Zeiringer, Matteo Tollemeto, Nazanin Zanjanizadeh Ezazi, Zhongyang Zhang, Leticia Hosta-Rigau, Jette Jacobsen, Ramona Jeitler, Eva Roblegg, Line Hagner Nielsen   +9 more
doaj   +2 more sources