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Overcoming Oral Cavity Barriers for Peptide Delivery Using Advanced Pharmaceutical Techniques and Nano-Formulation Platforms [PDF]
BiomedicinesTherapeutic peptides have gained significant attention due to their high specificity, potency, and safety profiles in treating various diseases. However, their clinical application via the oral route remains challenging.
Ali A. Amer +3 more
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A manganese (II)-based coordinative dendrimer with robust efficiency in intracellular peptide delivery [PDF]
Bioactive Materials, 2022 Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
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Peptide-based delivery of therapeutics in cancer treatment
Materials Today Bio, 2022 Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity.
Timothy Samec +4 more
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Peptide-Based Drug Delivery Systems
Medicina, 2021 Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and ...
Dmitriy Berillo +4 more
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Pharmaceutics, 2022 The clinical translation of therapeutic peptides is generally challenged by multiple issues involving absorption, distribution, metabolism and excretion. In this study, a macrophage membrane-coated poly(lactic-co-glycolic acid) (PLGA) nanodelivery system
Fang Wang +11 more
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Pharmaceutics, 2023 Cell-penetrating peptides (CPPs), such as penetratin, are often investigated as drug delivery vectors and incorporating d-amino acids, rather than the natural l-forms, to enhance proteolytic stability could improve their delivery efficiency.
Ditlev Birch +5 more
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A Computational Investigation of In Vivo Cytosolic Protein Delivery for Cancer Therapy
Pharmaceutics, 2021 The ability to specifically block or degrade cytosolic targets using therapeutic proteins would bring tremendous therapeutic opportunities in cancer therapy.
Camilo Torres +5 more
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Pharmaceuticals, 2023 Sarcopenia is a major public health issue that affects older adults. Myostatin inhibitory-D-peptide-35 (MID-35) can increase skeletal muscle and is a candidate therapeutic agent, but a non-invasive and accessible technology for the intramuscular delivery
Kohki Michiue +4 more
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Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
Biomolecules, 2021 The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies.
Olalekan Olanrewaju Bakare +5 more
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Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy
Pharmaceutics, 2021 Ang-(1-9) peptide is a bioactive vasodilator peptide that prevents cardiomyocyte hypertrophy in vitro and in vivo as well as lowers blood pressure and pathological cardiovascular remodeling; however, it has a reduced half-life in circulation, requiring a
Sabrina Sepúlveda-Rivas +5 more
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