Results 11 to 20 of about 2,035,646 (256)

Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies

Pharmaceutics
Effective drug delivery is essential for cancer treatment. Drug delivery systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of cancer treatment.
Yubo Wang, Lu Zhang, Chen Liu, Yiming Luo, Dengyue Chen   +4 more
doaj   +2 more sources

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine, Couet, William, Olivier, Jean-Christophe, Gaillard, Frédéric, Gaillard, Afsaneh, Muller, Jean-Marc   +5 more
core   +4 more sources

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain [PDF]

, 2004
The aim of this study was to evaluate glucose-bearing niosomes as a brain targeted delivery system for the vasoactive intestinal peptide (VIP). To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Dufès, Christine, Schätzlein, Andreas G., Gaillard, F., Uchegbu, I.F., Dufes, C., Muller, J.M., Gaillard, Frédéric, Olivier, Jean-Christophe, Muller, Jean-Marc, Schatzlein, A.G., Olivier, J.C.   +10 more
core   +4 more sources

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery [PDF]

, 2020
Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed.
Sadeghi, Amir, Sarkhel, Sanjay, Bahrpeyma, Sina, Toropainen, Elisa, Auriola, Seppo, Bhattacharya, Madhushree, Hagström, Marja, Urtti, Arto   +7 more
core   +1 more source

Assessment of CafA Targeted BAR-Encapsulated Nanoparticles against Oral Biofilms

Pharmaceutics, 2020
Porphyromonas gingivalis adherence to Streptococcus gordonii is a crucial initial event that facilitates the colonization of P. gingivalis, a key pathogen in periodontal disease.
Hetal Desai, Mohamed Y. Mahmoud, Jinlian Tan, Farnaz Minooei, Donald R. Demuth, Jill M. Steinbach-Rankins   +5 more
doaj   +1 more source

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

Pharmaceutics, 2021
Buccal drug delivery is a suitable alternative to invasive routes of drug administration. The buccal administration of insulin for the management of diabetes has received substantial attention worldwide.
Santosh Bashyal, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Shrawani Lamichhane, Sangkil Lee   +5 more
doaj   +1 more source

Live Cell Imaging by Förster Resonance Energy Transfer Fluorescence to Study Trafficking of PLGA Nanoparticles and the Release of a Loaded Peptide in Dendritic Cells

Pharmaceuticals, 2023
Our previous study demonstrated that a selected β-lactoglobulin-derived peptide (BLG-Pep) loaded in poly(lactic-co-glycolic acid) (PLGA) nanoparticles protected mice against cow’s milk allergy development.
Mengshan Liu, Chun Yin Jerry Lau, Irene Trillo Cabello, Johan Garssen, Linette E. M. Willemsen, Wim E. Hennink, Cornelus F. van Nostrum   +6 more
doaj   +1 more source

Rapid Release Polymeric Fibers for Inhibition of Porphyromonas gingivalis Adherence to Streptococcus gordonii

Frontiers in Chemistry, 2020
Active agents targeting key bacterial interactions that initiate biofilm formation in the oral cavity, may alter periodontitis progression; however, to date, specifically-targeted prophylactic and treatment strategies have been limited.
Mohamed Y. Mahmoud, Mohamed Y. Mahmoud, Mohamed Y. Mahmoud, Sonali Sapare, Sonali Sapare, Keegan C. Curry, Donald R. Demuth, Donald R. Demuth, Jill M. Steinbach-Rankins, Jill M. Steinbach-Rankins, Jill M. Steinbach-Rankins, Jill M. Steinbach-Rankins   +11 more
doaj   +1 more source

Selective DNA delivery to tumor cells using an oligoarginine-LTVSPWY peptide. [PDF]

PLoS ONE, 2014
DNA therapy for cancer requires efficient, selective and safe DNA delivery systems. Compared with other non-viral methods such as lipid or polymer-based DNA delivery vectors, peptide-based DNA delivery systems are biocompatible and biodegradable, which ...
Cheng Gong, Deng Pan, Fengwu Qiu, Pei Sun, Yu-Hui Zhang   +4 more
doaj   +1 more source

PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA

Drug Delivery, 2023
Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA ...
Yingying Xu, Yijing Zheng, Xuqiu Ding, Chengyan Wang, Bin Hua, Shilian Hong, Xiaoman Huang, Jiali Lin, Peng Zhang, Wei Chen   +9 more
doaj   +1 more source