Results 21 to 30 of about 2,035,646 (256)

Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances

Gels, 2022
Supramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules.
Carlos B. P. Oliveira, Valéria Gomes, Paula M. T. Ferreira, José A. Martins, Peter J. Jervis   +4 more
doaj   +1 more source

THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2020
Therapeutic nucleic acids must be formulated in delivery systems that permit them to be efficiently targeted to specific tissues within the body and to overcome the endosomal barrier to deliver these molecules to their intracellular target sites. GALA is
Hideyoshi Harashima, Ikramy Khalil
doaj   +1 more source

A method for concentrating lipid peptide DNA and siRNA nanocomplexes that retains their structure and transfection efficiency. [PDF]

, 2015
Nonviral gene and small interfering RNA (siRNA) delivery formulations are extensively used for biological and therapeutic research in cell culture experiments, but less so in in vivo and clinical research.
Hart, S.L., Zhou, Haiyan, Munye, Mustafa M, Hart, Stephen L, Munye, MM, Munye MM, Tagalakis AD, Tagalakis, Aristides D, Tagalakis, Aristides, White, Edward A, White, EA, Castellaro, S, Zhou, H, Zhou H, Castellaro S, White EA, Bienemann, A, White, E.A., McCarthy, David, Munye, M.M., Castellaro, Sara, Tagalakis, AD, Hart, SL, Bienemann, Ali S, McCarthy, D, Bienemann A, Hart SL, McCarthy D   +27 more
core   +1 more source

Development of a novel EGFR-targeted peptide for targeted delivery of drugs in anaplastic thyroid cancer [PDF]

, 2023
peer reviewedAnaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in human with a high proliferative and metastatic potential. The median survival of patients with ATC is of about 4 months after diagnosis and the
Journe, Fabrice, Saussez, Sven, Burtea, Carmen, Laurent, Sophie, Samuel Vandecasteele,, Marine Bougard,, Kahvecioglu, Zehra Cagla, Charlotte Rogien,   +7 more
core  

Enhanced Peptide Delivery and Sustainable Release of Pleurocidin Using N-Succinyl Chitosan Nanoparticle

Nano Biomedicine and Engineering, 2017
Chitosan is a natural polymer that can be modified into chemically different types. In order to imply biomedical applications, the chitosan dissolved in aqueous medium.
Giritharan Bupesh, Chinnaiyah Amutha, Sakthivel Vasanth, Tharaumasivam Siva Vijayakumar, Kannaiyah Pandian, Vellingiri Balachandar, Durai Rajan Gunasekaran   +6 more
doaj   +1 more source

Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation

International Journal of Nanomedicine, 2021
Santosh Bashyal,1 Jo-Eun Seo,1 Taekwang Keum,1,2 Gyubin Noh,1,2 Shrawani Lamichhane,1,2 Jeong Hwan Kim,1,2 Chang Hyun Kim,3 Young Wook Choi,3 Sangkil Lee1,2 1College of Pharmacy, Keimyung University, Daegu, Republic of Korea; 2Center for Forensic ...
Bashyal S, Seo JE, Keum T, Noh G, Lamichhane S, Kim JH, Kim CH, Choi YW, Lee S   +8 more
doaj  

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Peptide-DNA Co-Assembled Nanoparticles as a Nonviral Vector for Gene Delivery with High Transgene Expression

, 2023
Nonviral vectors for gene therapy are a safer alternative to viral vectors that elicit a harmful immune response. Artificial viruses combine the strengths of viral and nonviral vectors and have emerged to be safe and efficient gene delivery vectors ...
Ying Chau (1692013), Rong Ni (259332), Ruilu Feng (4534765)   +2 more
core   +1 more source

Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy

Frontiers in Immunology
Autoantigen-specific immunotherapy using peptides offers a more targeted approach to treat autoimmune diseases, but clinical implementation has been challenging. We previously showed that multivalent delivery of peptides as soluble antigen arrays (SAgAs)
Rebuma Firdessa-Fite, Stephanie N. Johnson, Camillo Bechi Genzano, Martin A. Leon, Amy Ku, Fernando A. Ocampo Gonzalez, Joshua D. Milner, Joshua O. Sestak, Cory Berkland, Cory Berkland, Remi J. Creusot   +10 more
doaj   +1 more source

Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols

Pharmaceutics, 2022
Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration, chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would hugely benefit from specific and potent peptide pharmaceuticals and their ...
Wafaa Alabsi, Basanth Babu Eedara, David Encinas-Basurto, Robin Polt, Heidi M. Mansour   +4 more
doaj   +1 more source