Results 41 to 50 of about 2,886,007 (195)
Desenvolvimento de estratégias farmacotécnicas para a melhoria das características biofarmacêuticas do mesilato de Saquinavir & avaliação da permeabilidade bucal do cloridrato de donepezila [PDF]
, 2014 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.Para fármacos com solubilidade aquosa limitada, estratégias farmacotécnicas visando a melhoria das ...
Caon, Thiago
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Buccal Drug Delivery: Past, Present and Future – A Review [PDF]
, 2011 The major hindrance for the absorption of a drug taken orally is extensive first pass metabolism or stability problems within the GI environment like instability in gastric pH and complexation with mucosal membrane.
A. Puratchikody +3 more
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Buccal Thin Films as Potent Permeation Enhancers for Cytisine Transbuccal Delivery
Membranes, 2022 Cytisine (CYT) is a powerful anti-smoking compound which could greatly benefit from transbuccal delivery because of both its unfavorable pharmacokinetics after oral administration and its intrinsic ability to permeate the buccal mucosa. This work aims to
Viviana De Caro +3 more
doaj +1 more source
In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films
Saudi Pharmaceutical Journal, 2020 The delivery of drugs via fast dissolving films is an effective alternative for drugs with low bioavailability when administered by other routes. This is the case of domperidone (DMP) an anti-emetic drug with low water solubility and vulnerable to ...
Gamal M. Zayed +4 more
doaj +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2022 Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride.
Kumara Swamy Samanthula +3 more
doaj +1 more source
, 2011 The study was aimed at the evaluation of N-vinyl pyrrolidone (NVP) incorporated polymethacrylic acid-chitosan microparticles for oral drug delivery applications. Poly (methacrylic acid)-chitosan (PMC) and poly(methacrylic acid-vinyl pyrrolidone)-chitosan
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Buccal Delivery of Nanoparticles
, 2020 The buccal route offers an alternative for drug administration due to its advantages, including the avoidance of the gastrointestinal tract, the hepatic first-pass, enzymatic degradation and chemical instability of certain molecules that would pose a ...
Ortiz, Andrea C., +3 more
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Polymer buccal films as innovative approach in drug delivery systems: a review
Materials Research ExpressBuccal films are sophisticated mucoadhesive dosage forms designed to administer therapeutic agents through the buccal mucosa. The field of buccal film research and development has progressed substantially, with numerous studies examining various polymers,
Tuty Fareyhynn Mohammed Fitri +3 more
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Development of Micropellets for Buccal Drug Delivery [PDF]
Scientia Pharmaceutica, 2010 Introduction: Pellets are an attractive dosage form in the gender specific and pediatric therapy, since they offer the possibility of patient adapted dosing. [...]
openaire +1 more source
Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
, 2023 Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its potential as an excipient for the design of mucoadhesive drug delivery systems.
Gergely Kali +4 more
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