Results 161 to 170 of about 3,231 (233)

An Efficient Strategy Based on Liquid–Liquid Extraction with Three-Phase Solvent System and High Speed Counter-Current Chromatography for Rapid Enrichment and Separation of Epimers of Minor Bufadienolide from Toad Meat

Journal of Agricultural and Food Chemistry, 2018
Denglang Zou
exaly   +2 more sources

A novel bufadienolide synthesis

Steroids, 1974
Abstract A simple two-step synthesis of bufadienolides is reported. It consists in the addition of the dimethyl acetal of chloroketene to a steroidal 20-methylene 21-aldehyde and in the treatment of the resulting 2,2-dimethoxy 3-chloro 2,3-dihydropyran with sodium methoxide in dimethylsulfoxide.
A, Bélanger, P, Brassard, G, Dionne, C R, Engel   +3 more
openaire   +2 more sources

ChemInform Abstract: BUFADIENOLIDE 20. MITT. 14BETA‐CHLOR‐BUFADIENOLIDE

Chemischer Informationsdienst, 1973
AbstractDie Epoxide (Ia) und (Ib) reagieren mit Chlorwasserstoff in Chloroform zu den Chlorhydrinen (IIa) und (IIb).
Y. KAMANO, G. R. PETTIT
openaire   +1 more source

The synthesis of cardenolide and bufadienolide aglycones, and related steroids bearing a heterocyclic subunit

Natural Product Reports, 2017
Michal Michalak, Karol Michalak, Jerzy Wicha   +2 more
exaly   +2 more sources

Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells

Oncology Reports, 2016
Bo Yuan, Hideki Hayashi, Sachiko Tanaka
exaly   +2 more sources

Unified Total Synthesis of Five Bufadienolides

Organic Letters, 2020
We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6.
Shinsuke Shimizu, Koichi Hagiwara, Hiroaki Itoh, Masayuki Inoue   +3 more
openaire   +2 more sources

Biosynthesis of bufadienolides—3β-hydroxycholanates as precursors in Bufo marinus bufadienolides synthesis

Biochemical Pharmacology, 1969
Abstract The biosynthesis of bufadienolides in toads ( Bufo marinus ) was investigated by measuring the radioactivity of resibufogenin, bufalin, marinobufagin and telocinobufagin in the venom following injection of some possible precursors labeled with 14 C or tritium.
C, Chen, M V, Osuch
openaire   +2 more sources

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

Molecular Cancer, 2014
Gamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, the underlying mechanism of CS-6 involved in anti-tumor activity remains poorly understood.
Wei Guo, Xiao-Kui Huo, Wuguo Deng
exaly   +2 more sources

Bufadienolides and their antitumor activity

Natural Product Reports, 2011
Since 1998, a great number of bufadienolides have been reported from plants, animals and plant cell suspensions, as well as from fungi and bacteria cultures. This review summarizes both new bufadienolides and those obtained from new sources, together with data regarding the antitumor activity of bufadienolide derivatives.
Gao, Huimin, McKinnon, Ruxandra, Kopp, Brigitte, Wang, Zhimin   +3 more
openaire   +3 more sources

Bufadienolides from animal and plant sources

Phytochemistry, 1998
Abstract Naturally occurring bufadienolides, which were isolated from both animal and plant sources and structurally elucidated in the period from 1967–1995, are reviewed and compiled.
Krenn, Liselotte, Kopp, Brigitte
openaire   +3 more sources