Results 151 to 160 of about 559,515 (356)

A practical framework for data collection in wireless sensor networks

open access: yes, 2008
Optimizing energy consumption for extending the lifetime in wireless sensor networks is of dominant importance. Groups of autonomous robots and unmanned aerial vehicles (UAVs) acting as mobile data collectors are utilized to minimize the energy ...
Hanoun, Samer, Nahavandi, Saeid
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Protecting Shoreland and Riparian Buffers Workshop (2007) [PDF]

open access: yes, 2008
The New Hampshire Estuaries Project (NHEP) organized and implemented a workshop on protecting shoreland and riparian buffers. A number of other organizations, including three regional planning commissions, NH Fish and Game Department, NH Department of ...
Hunter, Jennifer
core   +1 more source

ret2spec: Speculative Execution Using Return Stack Buffers

open access: yes, 2018
Speculative execution is an optimization technique that has been part of CPUs for over a decade. It predicts the outcome and target of branch instructions to avoid stalling the execution pipeline.
Acıiccmez Onur   +11 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

AWGN Channel Capacity of Energy Harvesting Transmitters with a Finite Energy Buffer [PDF]

open access: yesarXiv, 2013
We consider an AWGN channel with a transmitter powered by an energy harvesting source. The node is equipped with a finite energy buffer. Such a system can be modelled as a channel with side information (about energy in the energy buffer) causally known at the transmitter. The receiver may or may not have the side information.
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

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