Results 61 to 70 of about 571,212 (332)

Process redesign for effective use of product quality information in meat chains [PDF]

, 2012
To fulfil segmented consumer demand and add value, meat processors seek to exploit quality differences in meat products. Availability of product quality information is of key importance for this.
Rijpkema, Willem A., Rossi, Roberto, van der Vorst, Jack G.A.J.   +2 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Buffered 4% Articaine Reduces Pain and Enhances Anesthesia in Maxillary Third Molar Extractions: A Randomized, Double-Blind Split-Mouth Study

Biomedicines
Background/Objectives: Buffered local anesthetics are suggested to enhance patient comfort and anesthetic efficacy during dental procedures. However, their advantages over non-buffered solutions in maxillary third molar extractions remain under ...
Henning Staedt, Victor Palarie, Diana Heimes, Peter Ottl, Shengchi Fan, Peer W. Kämmerer   +5 more
doaj   +1 more source

Comparing circular and network buffers to examine the influence of land use on walking for leisure and errands

International Journal of Health Geographics, 2007
Background There is increasing interest in examining the influence of the built environment on physical activity. High-resolution data in a geographic information system is increasingly being used to measure salient aspects of the built environment and ...
Hall Alexander W, Schuurman Nadine, Oliver Lisa N   +2 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

Biomolecules, 2020
Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a dose ...
Anna A. Kudriaeva, George A. Saratov, Alena N. Kaminskaya, Vasiliy I. Vladimirov, Petro Yu Barzilovich, Alexey A. Belogurov   +5 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Avian response to conservation buffers in agricultural landscapes during winter

Wildlife Society Bulletin, 2014
Native herbaceous vegetation cover along row‐crop field edges (i.e., field buffers) increases breeding densities of many bird species. However, the effect of field buffers on bird species during the non‐breeding season is less understood.
Kristine O. Evans, L. Wes Burger Jr., Samuel K. Riffell, Mark D. Smith, Daniel J. Twedt, R. Randy Wilson, Shawchyi Vorisek, Catherine Rideout, Kate Heyden   +8 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Optimal Buffer Allocation in Flexible Manufacturing Systems Using Genetic Algorithm and Simulation

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Over the past few decades, buffer allocation problems have been investigated extensively. It is widely known that buffers play important roles in the manufacturing system, including preparing disruption and improving efficiency.
Suk-Jae JEONG, Hosang JUNG
doaj   +1 more source