Results 71 to 80 of about 582,767 (331)

Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

Biomolecules, 2020
Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a dose ...
Anna A. Kudriaeva, George A. Saratov, Alena N. Kaminskaya, Vasiliy I. Vladimirov, Petro Yu Barzilovich, Alexey A. Belogurov   +5 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Optimal Buffer Allocation in Flexible Manufacturing Systems Using Genetic Algorithm and Simulation

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Over the past few decades, buffer allocation problems have been investigated extensively. It is widely known that buffers play important roles in the manufacturing system, including preparing disruption and improving efficiency.
Suk-Jae JEONG, Hosang JUNG
doaj   +1 more source

Protecting Shoreland and Riparian Buffers Workshop (2007) [PDF]

, 2008
The New Hampshire Estuaries Project (NHEP) organized and implemented a workshop on protecting shoreland and riparian buffers. A number of other organizations, including three regional planning commissions, NH Fish and Game Department, NH Department of ...
Hunter, Jennifer
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Sistemas de información geográfica y análisis espaciales: un método combinado para realizar estudios panbiogeográficos Geographic information systems and spatial analysis: a combined method for panbiogeographic studies

Revista Mexicana de Biodiversidad, 2008
Uno de los estímulos en el progreso de la biogeografía ha sido el desarrollo y aplicación de nuevas tecnologías computacionales como los sistemas de información geográfica (SIG) y una variedad de métodos estadísticos espaciales. Dentro de la biogeografía
Jonathan Liria
doaj  

Buffer influence on magnetic dead layer, critical current and thermal stability in magnetic tunnel junctions with perpendicular magnetic anisotropy

, 2015
We present a thorough research on Ta/Ru-based buffers and their influence on features crucial from the point of view of applications of MTJs, such as critical switching current and thermal stability.
Ansermet, Jean-Philippe, Banasik, Monika, Chęciński, Jakub, Czapkiewicz, Maciej, Dubowik, Janusz, Frankowski, Marek, Głowiński, Hubert, Kanak, Jarosław, Powroźnik, Wiesław, Skowroński, Witold, Stobiecki, Tomasz, Wrona, Jerzy, Ziętek, Sławomir, Żywczak, Antoni   +13 more
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Modern middleware for the data acquisition of the Cherenkov Telescope Array

, 2015
The data acquisition system (DAQ) of the future Cherenkov Telescope Array (CTA) must be ef- ficient, modular and robust to be able to cope with the very large data rate of up to 550 Gbps coming from many telescopes with different characteristics. The use
Fuessling, Matthias, Jacquemier, Jean, Kosack, Karl, Lyard, Etienne, Oya, Igor, Walter, Roland, Wegner, Peter, Wu, Xin   +7 more
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source