Results 121 to 130 of about 663,058 (303)
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Foundations of Management, 2013 This paper is devoted to a solution for building a research knowledge base for the university. An experience in developing a specialised software for building such a knowledge base is presented.
Rybiński Henryk +4 more
doaj +1 more source
Tracking decision-making during architectural design [PDF]
, 2005 There is a powerful cocktail of circumstances governing the way decisions are made during the architectural design process of a building project. There is considerable potential for misunderstandings, inappropriate changes, change which give rise to ...
Cerulli, C +4 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Early Roman Finds from Acic Suat (Caraburun, Baia, Tulcea County) [PDF]
Peuce, 2017 This paper presents some preliminary results of the study of the pottery finds found in an early Roman building discovered in the settlement at Acic Suat (Caraburun, com. Baia, Tulcea county), in the 2015 campaign.
Alina MUŞAT-STREINU
doaj
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Usage of OLAP Cubes as a Data Model for DSS
Engineering ProceedingsA decision support system (DSS) is a software application designed to determine suitable actions for specific organizational situations. Its main component is a data repository analyzed to produce decisions.
Nikolai Scerbakov +2 more
doaj +1 more source
An implementation of Sub-CAD in Maple [PDF]
, 2015 Cylindrical algebraic decomposition (CAD) is an important tool for the investigation of semi-algebraic sets, with applications in algebraic geometry and beyond.
England, Matthew, Wilson, David
core +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source