Results 71 to 80 of about 132,806 (311)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Impact of earthquake-induced building debris on urban network functionality and citizen accessibility to urban functions

open access: yesFrontiers in Built Environment
Cities operate as complex socio-spatial systems, composed of interconnected networks formed by diverse physical and social components. Dynamic interactions among these components sustain the city’s functionality, support the fulfilment of fundamental ...
David Koren, Katarina Rus, Katarina Rus
doaj   +1 more source

Pre-disaster mapping with drones: an urban case study in Victoria, British Columbia, Canada [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2019
We report a case study using drone-based imagery to develop a pre-disaster 3-D map of downtown Victoria, British Columbia, Canada. This represents the first drone mapping mission over an urban area approved by Canada's aviation authority. The goal was to
M. Kucharczyk, C. H. Hugenholtz
doaj   +1 more source

Assessment of economically feasible net zero energy building concepts using the example of an office building in Germany

open access: yes, 2022
S.783-788Scope of this paper is the evaluation and assessment of a net zero energy building concept in respect of functionality and economic feasibility.
Beckert, Michael   +2 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Extending Information Delivery Specifications for digital building permit requirements

open access: yesDevelopments in the Built Environment
This paper examines the potential for extending the Information Delivery Specification (IDS) schema to facilitate its integration into the building permit process.
Simon Fischer   +4 more
doaj   +1 more source

Building/Community Resilience: identifying relationships that reduce disaster-related building downtime, improve functionality and build capacity [PDF]

open access: yes, 2017
Buildings, including those of historic significance, are increasingly at risk due to climate change, man-made and natural disasters. Capacity of a building to recover and adapt is informed by both internal and external factors that must be holistically ...
Maria Hurtado Ortiz   +4 more
core  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Effect of Temperature and Catalyst Concentration on Polyglycerol during Synthesis

open access: yesInternational Journal of Polymer Science, 2015
Morphology, molecular weight, polydispersity, functionality, and thermal properties are important characteristics when using polyglycerol as a building block in the development of materials for industrial applications such as hydrogels, surfactants ...
Carolina Ardila-Suárez   +2 more
doaj   +1 more source

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