Results 101 to 110 of about 4,562,946 (276)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Application of Integrated Building Information Modeling, IoT and Blockchain Technologies in System Design of a Smart Building

open access: yesEUSPN/ICTH, 2019
The Architecture, Engineering and Construction (AEC) industry has not adopted digital transformation enthusiastically like other industries, for instance, manufacturing, aerospace or finance.
I. Lokshina, M. Greguš, Wade Thomas
semanticscholar   +1 more source

Buildings as material banks using RFID and building information modeling in a circular economy

open access: yesProcedia CIRP, 2020
Currently, the Architecture, Engineering, and Construction community operates in an environmentally problematic linear economy by consuming non-renewable virgin materials, producing landfill waste, and increasing the overall environmental impact.
Samuel Copeland, M. Bilec
semanticscholar   +1 more source

Pushing architectural quality further [PDF]

open access: yes, 2008
In this paper, the intentions thriving the implementation of computational modeling of building physics as it is approached in the Architectural engineering courses at Ghent University are discussed.
Janssens, Arnold   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]

open access: yes, 2012
A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P   +12 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Effects of the Interactions Between LPS and BIM on Workflow in Two Building Design Projects [PDF]

open access: yes, 2014
Variability in design workflow causes delays and undermines the performance of building projects. As lean processes, the Last Planner System (LPS) and Building Information Modeling (BIM) can improve workflow in building projects through features that ...
Khan, Sheriz, Tzortzopoulos, Patricia
core  

What do peer support workers do? A job description. [PDF]

open access: yes, 2012
BackgroundThe extant literature suggests that poorly defined job roles make it difficult for peer support workers to be successful, and hinder their integration into multi-disciplinary workplace teams.
Dewa, Carolyn S   +2 more
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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