Results 111 to 120 of about 210,338 (264)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Fermi liquid and isotropic superconductivity of Hund scenario for bilayer nickelates

npj Quantum Materials
Recent experiments on bulk and thin film bilayer nickelate high-T c superconductors urge for clarification of their pairing mechanism. Debates exist on whether the hybridization or the Hund’s coupling between the nickel $${d}_{{x}^{2}-{y}^{2}}$$ d x 2 ...
Jiangfan Wang, Yi-feng Yang
doaj   +1 more source

Physicochemical vs. Chemical Pathways of Foam Inhibition: The Role of Cohesive Pressure and Specific Ion-Pairing

Surfaces
This study investigates the inhibitory effects of alkali metal chlorides lithium chloride, sodium chloride and potassium chloride (LiCl, NaCl, and KCl) on sodium dodecyl sulfate (SDS) foams, focusing on the transition from interfacial to bulk-driven ...
Niravkumar Raykundaliya, Vyomesh M. Parsana, Nikolay A. Grozev, Kristina Mircheva, Stanislav Donchev, Christomir Christov, Stoyan I. Karakashev, Dilyana Ivanova-Stancheva, Irina Yotova   +8 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Structural origin of fracture-induced surface charges in piezoelectric pharmaceutical crystals for engineering bulk properties

Nature Communications
Altering surface chemistry of functional materials is an attractive route to enable large property enhancements without sacrificing overall structural-order, appealing to diverse fields of application sciences; however, the same remains unexplored for ...
Kaustav Das, Ishita Ghosh, Soumalya Chakraborty, Amritha G. Nambiar, Sourav Maji, Sumanta K. Karan, Dinesh Kumar, Arvind K. Bansal, C. Malla Reddy   +8 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source