Results 1 to 10 of about 12,137 (255)

Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures [PDF]

PLoS ONE, 2013
Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA ...
Alexander Rotenberg, Gerard Berry, Frances E Jensen   +2 more
exaly   +7 more sources

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature Communications, 2022
Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Kasturi Roy, Laura Cancedda, Marco De Vivo   +2 more
exaly   +2 more sources

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

Neuropharmacology, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Philip Hampel, Douglas H Sweet, Wolfgang Löscher   +2 more
exaly   +3 more sources

Bumetanide in Patients with Alzheimer's Disease (BumxAD): A Phase IIa Clinical Trial [PDF]

Alzheimers Dement
Abstract Background Bumetanide is a potent diuretic administered orally and is FDA approved for the treatment of edema and hypertension. Recently, repurposing Bumetanide as an Alzheimer`s disease (AD) medication was proposed based on data that showed Bumetanide “flipped” the APOE genotype‐dependent transcriptomic signatures in AD mouse and cell culture
Kmiecik M, Chu M, Zhou A, Skylar‐Scott I, Samudra N, Tripathi P, Coburn M, Wilson T, He Z, Haddad F, Wyss‐Coray T, Sha S, Greicius M, Younes K.   +13 more
europepmc   +2 more sources

Outpatient loop diuretic use and the effect of natriuresis-guided diuretic therapy: A prespecified sub-analysis of the PUSH-AHF study. [PDF]

Eur J Heart Fail
The effects of natriuresis‐guided diuretic therapy in patients with acute decompensated heart failure, depending on outpatient loop diuretic use. HR, hazard ratio; NG, natriuresis‐guided; SOC, standard of care. Aims Diuretic resistance is frequently observed in patients with acute decompensated heart failure (ADHF), specifically in those with chronic ...
Zonneveld LEEC, Beldhuis IE, Qin H, van Veldhuisen DJ, Coster JE, Nieuwland W, Krikken JA, van der Meer P, Voors AA, Damman K, Ter Maaten JM.   +10 more
europepmc   +2 more sources

Sildenafil is a candidate drug for Alzheimer’s disease: Mechanism‐of‐action observation in patient iPSC‐derived brain organoids and a 5xFAD mouse model [PDF]

Alzheimers Dement
Abstract Background We previously identified Sildenafil (a phosphodiesterase type 5 (PDE5) inhibitor) as a candidate drug in Alzheimer’s Disease (AD) using an in silico network medicine approach. However, the clinically meaningful effect size and mechanism‐of‐action of sildenafil in AD treatment is still unclear.
Li Y, Gohel D, Pieper A, Cummings J, Cheng F.   +4 more
europepmc   +2 more sources

Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol

BMC Psychiatry, 2022
Background Bumetanide is a selective NKCC1 chloride importer antagonist which is being repurposed as a mechanism-based treatment for neurodevelopmental disorders (NDDs).
Lisa Geertjens, Gianina Cristian, Eva Haspels, Jennifer Ramautar, Gert Jan van der Wilt, Matthijs Verhage, Hilgo Bruining   +6 more
doaj   +2 more sources

Euglycemic Ketoacidosis Induced by Dapagliflozin in a Non-Diabetic Patient With Cardiac Amyloidosis. [PDF]

Clin Case Rep
ABSTRACT Dapagliflozin, though beneficial in heart failure, can rarely cause euglycemic ketoacidosis even in non‐diabetic patients. Clinicians should maintain a high index of suspicion for metabolic acidosis in patients on SGLT2 inhibitors presenting with unexplained illness, regardless of blood glucose level.
Hamoud SAS, Harding E.
europepmc   +2 more sources

Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation [PDF]

Scientific Reports
Neonatal exposure to sevoflurane has been associated with neurodevelopmental impairments. However, the mechanisms underlying increased susceptibility to stress-related neurological disorders remain unclear.
Bi-ying Yuan, Li-hui Shan, Jiang Zou, Xiao-hai Xie, Jia-qi Gan, Ben-zhen Chen   +5 more
doaj   +2 more sources

Structural basis for human NKCC1 inhibition by loop diuretic drugs [PDF]

The EMBO Journal
Na+–K+–Cl− cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are
Yongxiang Zhao, Pietro Vidossich, Biff Forbush, Junfeng Ma, Jesse Rinehart, Marco De Vivo, Erhu Cao   +6 more
doaj   +2 more sources