Results 91 to 100 of about 12,137 (255)

Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously

open access: yesFrontiers in Molecular Neuroscience, 2017
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability and autism. The disorder is characterized by altered synaptic plasticity in the brain.
Shimriet Zeidler   +3 more
doaj   +1 more source

Priprava uzoraka i određivanje diuretika u tjelesnim tekućinama čovjeka pomoću RPHPLC [PDF]

open access: yes, 2006
This article described reverse phase high-performance liquid chromatography (RPHPLC) methods for determination of diuretics in different human body fluids (whole blood, plasma, serum or urine).
DRAGICA ZENDELOVSKA, TRAJČE STAFILOV
core   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 994-1014, November 2025.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano   +8 more
wiley   +1 more source

Atherosclerotic renal artery stenosis is prevalent in cardiorenal patients but not associated with left ventricular function and myocardial fibrosis as assessed by cardiac magnetic resonance imaging [PDF]

open access: yes, 2012
Background Atherosclerotic renal artery stenosis (ARAS) is common in cardiovascular diseases and associated with hypertension, renal dysfunction and/or heart failure.
AT Hirsch   +45 more
core   +3 more sources

Bumetanide-related effect on attention to face parts in children and adolescents with autism spectrum disorder using the eye tracking algorithm [PDF]

open access: diamond, 2020
Ahmad Delrobaee   +5 more
openalex   +1 more source

Bumetanide-Enhanced Phenobarbetal in Neonatal Seizure Model

open access: yesPediatric Neurology Briefs, 2008
Anticonvulsant efficacy of phenobarbital, bumetanide, and a combination of these drugs was studied in an in vitro hippocampal rat pup (4-7 days) preparation, with recurrent seizures induced by exposure to low-Mg solution, at the Department of Neurology ...
J Gordon Millichap
doaj   +1 more source

Analgesic Effect of Bumetanide on Neuropathic Pain in Patients With Spinal Cord Injury.

open access: green, 2021
Farinaz Nasirinezhad   +5 more
openalex   +2 more sources

Neonatal Seizure Models to Study Epileptogenesis

open access: yesFrontiers in Pharmacology, 2018
Current therapeutic strategies for epilepsy include anti-epileptic drugs and surgical treatments that are mainly focused on the suppression of existing seizures rather than the occurrence of the first spontaneous seizure.
Yuka Kasahara   +2 more
doaj   +1 more source

NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons [PDF]

open access: yes, 2015
GABA A receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular
Bosch, Ludo Van Den   +3 more
core   +1 more source

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