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Novel Pharmaceutical Cocrystals and Salts of Bumetanide
, 2020New crystalline forms of bumetanide, namely four cocrystals, two salts and one salt-cocrystal were crystallized. Urea and lactams such as valerolactam, caprolactam, N-methyl caprolactam formed cocrystals with bumetanide whereas 4-aminopyridine gave a ...
Suryanarayana Allu +3 more
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In vitro Metabolism of Bumetanide
Pharmaceutical Research, 1984A new metabolite of the diuretic drug bumetanide, the 4-[(4'-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed.
GROSA, Giorgio +3 more
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Bumetanide for Autism Spectrum Disorder in Children: A Review of Randomized Controlled Trials
The Annals of Pharmacotherapy, 2018Objective: To evaluate clinical trials using bumetanide in autism spectrum disorder (ASD) treatment. Data Sources: PubMed and Ovid MEDLINE (1946 to October 2018) were searched using terms bumetanide and autism.
B. J. James +4 more
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Bumetanide attenuates acute lung injury by suppressing macrophage activation
Biochemical Pharmacology, 2018Graphical abstract Figure. No Caption available. Abstract Bumetanide is a potent loop diuretic that acts as an inhibitor of sodium‐potassium‐chloride cotransporter 2 (NKCC2) and its isoform NKCC1. Although the expression of NKCC2 is limited to the kidney,
Chin-Mao Hung +3 more
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Indomethacin and the response to bumetanide
Clinical Pharmacology and Therapeutics, 1980Pretreatment of 8 normal subjects with 100 mg indomethacin decreased the response to bumetanide; cumulative 4-hr excretion of sodium due to 1.0 mg of bumetanide was reduced from 276 +/- 22.9 to 202 +/- 20.9 mEq (p less than 0.003). Effects on volume and Cl paralleled those on Na while K excretion was not affected.
Craig Brater +3 more
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Developmental Pharmacology and Therapeutics, 2017
Bumetanide binding to human serum albumin was studied using ultrafiltration. The first stoichiometric binding constant for bumetanide is 6.4 × 10^4 M^-1. Bumetanide competes with bilirubin for human serum albumin binding, having a K(Displ) (displacement constant) of 6.2 × 10^3 M^-1 measured by the peroxidase method.
A, Robertson, W, Karp
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Bumetanide binding to human serum albumin was studied using ultrafiltration. The first stoichiometric binding constant for bumetanide is 6.4 × 10^4 M^-1. Bumetanide competes with bilirubin for human serum albumin binding, having a K(Displ) (displacement constant) of 6.2 × 10^3 M^-1 measured by the peroxidase method.
A, Robertson, W, Karp
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Bumetanide lowers acute hydrocephalus in a rat model of subarachnoid hemorrhage
Acta Neurochirurgica, 2022T. Metayer +7 more
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Supramolecular Synthons in Bumetanide Cocrystals and Ternary Products
, 2017A novel design strategy for cocrystals of the diuretic sulfonamide drug bumetanide (BUM) with carboxamides is reported based on reliable supramolecular synthons.
Suryanarayana Allu +3 more
semanticscholar +1 more source