Results 31 to 40 of about 12,137 (255)

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype phenotype correlations [PDF]

, 1996
We have generated a mouse carrying the human G551D mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR) by a one-step gene targeting procedure.
Alton, Ewfw, Delaney, S. J., Dorin, J. R., Farley, R., Hume, D. A., Lamb, D., Lovelock, P. K., Lunn, D. P., Porteous, D. J., Smith, S. N., Thomson, S. A., Wainwright, B. J.   +11 more
core   +2 more sources

Failure of bumetanide to improve outcome after intracerebral hemorrhage in rat.

PLoS ONE, 2019
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function ...
Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz, Colby A Nadeau, Paul S Brar, Julia J A Clark, Frederick Colbourne   +6 more
doaj   +1 more source

Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4–5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial

BMC Nephrology, 2022
Background The co-administration of loop diuretics with thiazide diuretics is a therapeutic strategy in patients with hypertension and volume overload.
Fabio Solis-Jimenez, Lucia Monserrat Perez-Navarro, Ricardo Cabrera-Barron, Jesus Antonio Chida-Romero, Geovana Martin-Alemañy, Edgar Dehesa-López, Magdalena Madero, Rafael Valdez-Ortiz   +7 more
doaj   +1 more source

Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca2+ Overload in Neurons via the Inhibition of Voltage-Gated Ca2+ and Na+ Channels

Frontiers in Pharmacology, 2021
One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state.
Christopher Katnik, Javier Cuevas
doaj   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Bumetanide for Irritability in Children With Sensory Processing Problems Across Neurodevelopmental Disorders: A Pilot Randomized Controlled Trial

Frontiers in Psychiatry, 2022
BackgroundTreatment development for neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is impeded by heterogeneity in clinical manifestation and underlying etiologies.
Dorinde M. van Andel, Jan J. Sprengers, Mandy G. Keijzer-Veen, Annelien J. A. Schulp, Marc R. Lillien, Floortje E. Scheepers, Hilgo Bruining   +6 more
doaj   +1 more source

Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers [PDF]

, 2018
Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3 - secretion to total cyclic adenosine monophosphate (cAMP ...
Avula, L.R. (Leela Rani), Donowitz, M. (Mark), Foulke-Abel, J. (Jennifer), Jonge, H.R. (Hugo) de, Singh, V. (Varsha), Tse, C.-M. (Chung-Ming), Yin, J. (Jianyi)   +6 more
core   +5 more sources

Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury

Neural Regeneration Research, 2020
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.
Chao-Yang Tan, Yan-Ping Wang, Yuan-Yuan Han, Bi-Han Lu, Wei Ji, Li-Cang Zhu, Yang Wang, Wen-Yan Shi, Li-Ya Shan, Liang Zhang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +12 more
doaj   +1 more source

The GABA Polarity Shift and Bumetanide Treatment: Making Sense Requires Unbiased and Undogmatic Analysis

Cells, 2022
GABA depolarizes and often excites immature neurons in all animal species and brain structures investigated due to a developmentally regulated reduction in intracellular chloride concentration ([Cl−]i) levels.
Yehezkel Ben-Ari, Enrico Cherubini
doaj   +1 more source

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

Molecular Autism, 2020
Background Tuberous sclerosis complex (TSC) is an autosomal dominant disease that affects multiple organs including the brain. TSC is strongly associated with broad neurodevelopmental disorders, including autism spectrum disorder symptomatology ...
Dorinde M. van Andel, Jan J. Sprengers, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Hilgo Bruining   +5 more
doaj   +1 more source