Results 41 to 50 of about 12,137 (255)

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]

, 2014
Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E, Goda S, Kaila K, Mares P, Randall J, Soul J, Volpe J, Walker PC   +7 more
core   +1 more source

Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia

Neural Regeneration Research, 2016
Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia.
Wang-shu Xu, Xuan Sun, Cheng-guang Song, Xiao-peng Mu, Wen-ping Ma, Xing-hu Zhang, Chuan-sheng Zhao   +6 more
doaj   +1 more source

Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study

Frontiers in Neuroscience, 2022
Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair ...
Erika L. Juarez-Martinez, Erika L. Juarez-Martinez, Dorinde M. van Andel, Jan J. Sprengers, Arthur-Ervin Avramiea, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen, Hilgo Bruining, Hilgo Bruining, Hilgo Bruining, Hilgo Bruining   +13 more
doaj   +1 more source

A Randomised Controlled Trial of Bumetanide in the Treatment of Autism in Children [PDF]

, 2013
Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA ...
Ben-Ari, Yehezkel, Degrez, Céline, Grandgeorge, Marine, Hadjikhani, Nouchine, Josse, Florent, Lemonnier, Éric, Phelep, Morgane, Tyzio, Roman   +7 more
core   +1 more source

Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats

Frontiers in Pharmacology, 2022
Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is an integral part of neural interaction. Action of the GABAA receptor depends on the amount of intracellular chloride.
Shiva Hashemizadeh, Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini ravandi, Mahmoudreza Hadjighassem, Mahmoudreza Hadjighassem   +9 more
doaj   +1 more source

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]

, 2017
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder, Berdondini, Luca, De Pietri Tonelli, Davide, Marinaro, Federica   +3 more
core   +2 more sources

Pharmacotherapy for neonatal seizures: current knowledge and future perspectives [PDF]

, 2016
Seizures are the most common neurological emergencies in the neonatal period and are associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 term births and population-based studies suggest that they occur even more ...
Boylan, Geraldine B., Cryan, John F., Donovan, Maria D., Griffin, Brendan T., Kharoshankaya, Liudmila   +4 more
core   +1 more source

Food: An Unrecognized Source of Loop Diuretic Resistance [PDF]

, 2004
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90131/1/phco.24.6.630.34736 ...
Bard, Robert L., Bleske, Barry E., Nicklas, John M.   +2 more
core   +1 more source

ROLE OF Na+, K+, 2Cl– -COTRANSPORTER AND POTASSIUM CONDUCTIVITY IN THE REALIZATION OF THE EFFECT OF CARBON MONOXIDE, IN THE SMOOTH MUSCLE OF VISCERAL ORGANS

Бюллетень сибирской медицины, 2016
The aim of this study was to investigate the role of the Na+, K+, 2Cl– -transport and potassium conductance, in the implementation of the effects of carbon monoxide in the SMC taenia coli and ureter of guinea pig.Materials and methods.
A. V. Skvortsov, M. A. Medvedev, V. B. Studnitsky, I. V. Kovalev, Y. A. Pogudin, S. V. Gusakova, O. I. Antonov, J. G. Birulina   +7 more
doaj   +1 more source

Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex

Frontiers in Neurology, 2017
BackgroundRecent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic ...
Chantal Vlaskamp, Simon-Shlomo Poil, Floor Jansen, Klaus Linkenkaer-Hansen, Sarah Durston, Bob Oranje, Hilgo Bruining   +6 more
doaj   +1 more source