Results 51 to 60 of about 212 (104)

A public, cross‐reactive glycoprotein epitope confounds Ebola virus serology

Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Abstract Ebola disease (EBOD) in humans is a severe disease caused by at least four related viruses in the genus Orthoebolavirus, most often by the eponymous Ebola virus. Due to human‐to‐human transmission and incomplete success in treating cases despite promising therapeutic development, EBOD is a high priority in public health research.
Markus H. Kainulainen, Jessica R. Harmon, Elif Karaaslan, Jackson Kyondo, Amy Whitesell, Sam Twongyeirwe, Jason H. Malenfant, Jimmy Baluku, Aaron Kofman, Éric Bergeron, Michelle A. Waltenburg, Luke Nyakarahuka, Stephen Balinandi, Caitlin M. Cossaboom, Mary J. Choi, Trevor R. Shoemaker, Joel M. Montgomery, Christina F. Spiropoulou   +17 more
wiley   +1 more source

Estimated Transmissibility and Case Fatality Rate of Bundibugyo Virus, Uganda, 2007

Emerging Infectious Diseases
Because the epidemiology of Bundibugyo virus remains unclear, we reanalyzed the first recognized outbreak (Uganda, 2007). Adjusting for case under-ascertainment and the effect of control measures, we estimated the effective reproduction number (1.55 ...
Bianca de Padua, Andrei R. Akhmetzhanov
doaj   +1 more source

2026 Bundibugyo virus outbreak: the role of genomics in Orthoebolavirus outbreaks

Microbial Genomics
Central Africa is currently experiencing its third recorded outbreak of Bundibugyo virus, one of three orthoebolaviruses capable of causing lethal haemorrhagic fevers in humans with person-to-person transmission. The first genomes from this outbreak have been made available, creating an opportunity to reflect on the role of genomics in previous ...
openaire   +1 more source

Fruit–frugivore dependencies are important in Ebolavirus outbreaks in Sub‐Saharan Africa

Ecography, Volume 2024, Issue 10, October 2024.
Ebolaviruses have the ability to infect a wide variety of species, with many African mammals potentially serving either as primary reservoirs or secondary amplifying hosts. Previous work has shown that frugivorous bats and primates are often associated with spillover and outbreaks.
Mekala Sundaram, Mireya Dorado, Benedicta Akaribo, Antoine Filion, Barbara A. Han, Nicole L. Gottdenker, John P. Schmidt, John M. Drake, Patrick R. Stephens   +8 more
wiley   +1 more source

YF17D‐based vaccines – standing on the shoulders of a giant

European Journal of Immunology, Volume 54, Issue 5, May 2024.
Graphical Abstract: Live‐attenuated yellow fever vaccine (YF17D) has emerged as platform to develop prophylactic and therapeutic vaccines against infectious diseases and cancer. In this review, we summarize the unique polyfunctional immunity endowed by original YF17D, and the progress and challenges of recombinant YF17D‐based vaccines for unmet medical
Lorena Sanchez‐Felipe, Yeranddy A. Alpizar, Ji Ma, Lotte Coelmont, Kai Dallmeier   +4 more
wiley   +1 more source

From Ebola response to adaptable preparedness beyond a single virus

Tropical Medicine and Health
The Democratic Republic of the Congo (DRC) has been an important setting for Ebola innovation, including ring vaccination with recombinant vesicular stomatitis virus-based Ebola vaccine and the integration of clinical research into emergency response ...
Justin Kambale Kahingi, Clovis Mbokolo Bolima, Jonas Belanga Bola, Benny Bebedi Nkamba, Eric Ilonga Mpeti, Claudia Mbanda Mpunza, Héritier Bekoka Wanga, Relindis Mpembe Ngila, Jean Belito Nyimi, Roméo Okasuma Djela, Jacky Mungolongolo Mabaya, Prosper Ndjate Olongo, André Kanjinga Ngoyi, Lionel Shotsha Asamboa, Gédéon Bongo Ngiala, Yves Nkayilu Tungulo, Nelly Kola Nsimba, Rosie Mubindukila Nzamba, Max Seke Vangu, Jean Paul Nzundu Mbo, Serge Inia Aluna, Thierry Tangou Tabou   +21 more
doaj   +1 more source

Early Action Review of Detection, Notification, and Response Timeliness during Cross-Border Bundibugyo Virus Disease Outbreak, Uganda, 2026

Emerging Infectious Diseases
Bundibugyo virus disease (BVD), an Ebola virus species with no licensed vaccine or therapeutic, reemerged in May 2026 as a cross-border outbreak in Uganda and the Democratic Republic of the Congo. During a 2-day workshop, July 8–9, 2026, we conducted an
Joshua Kayiwa, Mudarshiru Bbuye, Ritah Atuhaire, Doreen Nyakato, Mathew Tut, Bayad Nozad, Jovan Baryamujura, Bernard Lubwama, Solome Okware, Pamela Kajumba, Grace Akello, Bonny Kintu, Rebecca Kahunde, Dativa Aliddeki, Motuma Guyassa, Lydia Nakiire, Felix Ocom, Paul Mbaka, Peter Elyanu, Allan Muruta, Atek Kagirita, Charles Olaro   +21 more
doaj   +1 more source

Whole-Genome Sequencing for High-Consequence Emerging RNA Viruses: Strategy Selection for Bundibugyo Virus Disease Under 2026 Outbreak Constraints

Viruses
Whole-genome sequencing (WGS) is central to outbreak response for high-consequence ribonucleic acid (RNA) viruses, but useful genomes depend on workflow design, sample quality, biosafety, diagnostic breadth, infrastructure, and bioinformatics as much as ...
Katharina Kopp
doaj   +1 more source

Ebola Disease: An Updated Review in the Context of the 2026 Bundibugyo Virus Outbreak

Mediterranean Journal of Infection, Microbes and Antimicrobials
Ebola disease (EBOD) is a severe viral illness with a high mortality rate caused by viruses of the genus Orthoebolavirus within the family Filoviridae. The emergence of a new outbreak caused by Bundibugyo virus (BDBV) in Ituri Province of the Democratic ...
Fahriye Melis Gürsoy Kurtoğlu, Aliye Baştuğ   +1 more
doaj   +1 more source

Community event-based surveillance as trust infrastructure for

International Journal of Infectious Diseases
The 2026 outbreak of Ebola caused by Bundibugyo virus disease in the Democratic. Republic of the Congo and Uganda highlights persistent gaps in centralized outbreak surveillance, particularly in settings affected by insecurity, displacement, cross-border
Pieter Baker
doaj   +1 more source