Results 101 to 110 of about 6,619 (255)

Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins

Viruses, 2016
The Bunyaviridae is a family of arboviruses including both plant- and vertebrate-infecting representatives. The Tospovirus genus accommodates plant-infecting bunyaviruses, which not only replicate in their plant host, but also in their insect thrips ...
Marcio Hedil, Richard Kormelink
doaj   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source

RNA Encapsidation and Packaging in the Phleboviruses

Viruses, 2016
The Bunyaviridae represents the largest family of segmented RNA viruses, which infect a staggering diversity of plants, animals, and insects. Within the family Bunyaviridae, the Phlebovirus genus includes several important human and animal pathogens ...
Katherine E. Hornak, Jean-Marc Lanchy, J. Stephen Lodmell   +2 more
doaj   +1 more source

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +1 more source

Identification of the Bunyamwera bunyavirus transcription termination signal

Journal of General Virology, 2006
Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae, which comprises segmented RNA viruses. Each of the BUNV negative-strand segments, small (S), medium (M) and large (L), serves as template for two distinct RNA-synthesis activities: (i) replication to generate antigenomes that are in turn replicated to yield further ...
John N, Barr, John W, Rodgers, Gail W, Wertz   +2 more
openaire   +2 more sources

Crimean-Congo Hemorrhagic Fever Virus for Clinicians—Epidemiology, Clinical Manifestations, and Prevention

Emerging Infectious Diseases
Crimean-Congo hemorrhagic fever (CCHF) is a tickborne infection that can range from asymptomatic to fatal and has been described in >30 countries. Early identification and isolation of patients with suspected or confirmed CCHF and the use of appropriate
Maria G. Frank, Gretchen Weaver, Vanessa Raabe   +2 more
doaj   +1 more source

Tamdy virus pathogenesis in immunocompetent and immunocompromised mouse models

Virulence
Tamdy virus (TAMV) is one of the zoonotic tick-borne bunyaviruses that have emerged as global public health threats in recent decades. To date, however, TAMV pathogenesis remains poorly understood.
Mingxue Cui, Hua-Chen Zhu, Xiurong Wang, Ying Cao, Di Liu, Michael J. Carr, Yi Guan, Hong Zhou, Weifeng Shi   +8 more
doaj   +1 more source

Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]

, 2015
UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya, Boon, Adrianus C.M., Brien, James D, Diamond, Michael S, Ebihara, Hideki, Liu, Gai, Mühlberger, Elke, Olejnik, Judith, Pinto, Amelia K, Proença-Módena, José Luiz, Szretter, Kristy J, White, James P, Williams, Graham D   +12 more
core   +3 more sources

Rift Valley fever virus activates multiple cell death pathways in neurons

Journal of Virology
Neuronal injury and death contribute to long-term impairments and lethality during viral encephalitis. Rift Valley fever virus (RVFV), an arbovirus with epidemic potential, can manifest as late-onset encephalitis in humans, yet this disease outcome ...
Kaleigh A. Connors, Zachary D. Frey, Matthew J. Demers, Morgan Midgett, Connor Williams, Douglas S. Reed, Zachary P. Wills, Amy L. Hartman   +7 more
doaj   +1 more source

Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation [PDF]

, 2015
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to ...
Chan, CP, Chaudhary, V, Fung, SY, Jin, D, Kok, KH, Li, C, Li, D, Liang, M, Lui, PY, Wang, PH, Yuen, KS, Zhang, S   +11 more
core   +1 more source