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PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
MedComm, Volume 6, Issue 8, August 2025.The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang +10 more
wiley +1 more source
Cardiac arrest in a child during a combined general epidural anesthesia procedure [PDF]
, 2005 An increased risk of perioperative cardiac arrest in children, in comparison to adults, has been recognized. A number of factors associated with perioperative cardiac arrest have been identified, including young age, comorbidities, and emergency ...
Prabakti, Yudhi +4 more
core
Local and Regional Anesthesia, 2019 Ann-Kristin Schubert,1 Stefan Müller,1 Hinnerk Wulf,1 Thorsten Steinfeldt,1,2 Thomas Wiesmann11Department of Anesthesiology and Intensive Care Medicine, University Hospital Marburg, Philipps University of Marburg, Marburg, Germany; 2Department of ...
Schubert AK +4 more
doaj
The free energy of biomembrane and nerve excitation and the role of anesthetics
, 2018 In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference ...
Heimburg, Thomas +3 more
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Orthopaedic Surgery, Volume 17, Issue 8, Page 2255-2265, August 2025.Nerve blocks significantly improve pain management, reduce opioid consumption, and lower adverse reactions compared to intravenous analgesia in elderly patients with hip fractures. ABSTRACT Pain management in elderly patients with hip fractures has received more and more attention, which is crucial for promoting recovery and reducing complications.
Yuping Liu, Li Zhou, Xin Wang
wiley +1 more source
BUPIVACAINE: A CLINICAL ASSESSMENT IN LUMBAR EXTRADURAL BLOCK
, 1969 J. W. Downing
openalex +1 more source