Results 71 to 80 of about 39,408 (252)

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats

, 2019
Benquan Liu,1 Jiemei Ji,1 Qing Feng,1 Xi Luo,1 Xiurong Yan,1 Yuxia Ni,2 Yajun He,1 Zhongxuan Mao,1 Jingchen Liu1 1Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic
Ni Y, Liu J, He Y, Liu B, Ji J, Luo X, Yan X, Feng Q, Mao Z   +8 more
core  

AMPK attenuates bupivacaine-induced neurotoxicity

, 2010
Bupivacaine has been widely used as a long-acting local anesthetic. However, evidence strongly suggests that bupivacaine causes apoptosis. AMP-activated protein kinase (AMPK) regulates metabolic homeostasis and mediates cellular protection from stress ...
Lee, S.J., Kim, H.J., Shin, T.J., Kang, I.S., Ha, J.H., Lee, S.C.   +5 more
core   +1 more source

Liposomal Bupivacaine vs. Plain Bupivacaine with Dexamethasone for Rhomboid Intercostal Block in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Non-inferiority Trial

Pain and Therapy
Introduction Effective and sustained postoperative analgesia is essential to enhance recovery after video-assisted thoracoscopic surgery (VATS). Liposomal bupivacaine, a multivesicular formulation enabling extended local anesthetic release, offers a ...
Lei Xie, Yazhi Xi, Xinyao He, Mingzi An, Xiaoyu Jia, Zhenping Li, Tao Chen, Qinghe Zhou   +7 more
doaj   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

Beyond the Epidural: Reframing Analgesia for the Modern Oesophagectomy

ANZ Journal of Surgery, EarlyView.
A novel analgesic framework for minimally invasive oesophagectomy to facilitate functional recovery.
William Thomas Birkett, Geraldine Ooi, Bethany White, Hamish Shilton, Liang Low, Paul Cashin, Walston Reginald Martis   +6 more
wiley   +1 more source

Infiltration of liposome bupivacaine into the transversus abdominis plane for postsurgical analgesia in robotic laparoscopic prostatectomy: a pilot study

, 2014
Andrew Sternlicht,1 Max Shapiro,1 Gary Robelen,1 Usha Vellayappan,1 Ingolf A Tuerk2 1Department of Anesthesiology and Pain Medicine, 2Department of Urology, Steward St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA ...
Robelen G, Tuerk IA, Sternlicht A, Shapiro M, Vellayappan U   +4 more
core  

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

, 2011
The hERG voltage-gated potassium channel mediates the cardiac I(Kr) current, which is crucial for the duration of the cardiac action potential. Undesired block of the channel by certain drugs may prolong the QT interval and increase the risk of malignant
Sintra Grilo, Liliana, Hugues Abriel, Antoine Daina, Carrupt, Pierre-Alain, Pierre-Alain Carrupt, Daina, Antoine, Liliana Sintra Grilo, Abriel, Hugues   +7 more
core   +1 more source

The bupivacaine controversy [PDF]

Anaesthesia, 1983
D G, Beeby, J G, Jenkins
openaire   +2 more sources

Shoulder‐Tip Pain After Laparoscopic Surgery: A Narrative Review of Intraperitoneal Anaesthesia

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background and Aims Shoulder‐tip pain is a common and distressing side effect following laparoscopic surgery. Standard systemic analgesic regimens are used to manage postoperative pain but are often associated with side effects such as nausea and vomiting.
Jason Arsanious, Alice Osterwalder, Sarah K. Thompson   +2 more
wiley   +1 more source