Results 61 to 70 of about 80,732 (295)

Translocator protein positron emission tomography as a biomarker for posttraumatic epilepsy and behavioral comorbidities following traumatic brain injury

Epilepsia, EarlyView.
Abstract Objective Traumatic brain injury (TBI) induces widespread and persistent neuroinflammation, which is increasingly recognized as a key contributor to chronic sequelae including posttraumatic epilepsy (PTE), cognitive deficits, and neuropsychiatric disturbances. However, reliable biomarkers for identifying individuals at risk for these long‐term
Mohit Javalgekar, Peravina Thergarajan, Juliana Silva, Emma Braine, Robert Brkljača, Pablo M. Casillas‐Espinosa, Stefanie Dedeurwaerdere, Mohammad Haskali, Usama Kamil, Terence J. O'Brien, Nigel C. Jones, David K. Wright, Bianca Jupp, Lucy Vivash, Idrish Ali   +14 more
wiley   +1 more source

Post-operative pain and analgesic requirements after paravertebral block for mastectomy: A randomized controlled trial of different concentrations of bupivacaine and fentanyl

Indian Journal of Anaesthesia, 2012
Background: Paravertebral block (PVB) is useful for post-operative analgesia after breast surgery. Bupivacaine is used for PVB at higher concentrations (0.5%), which may lead to systemic toxicity after absorption.
V Bhuvaneswari, Jyotsna Wig, Preethy J Mathew, Gurpreet Singh   +3 more
doaj   +1 more source

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study

Hernia, 2019
Currently available local anesthetics have not demonstrated sufficient analgesia beyond 12–24 h postoperatively. The purpose of the study was to assess the safety and efficacy of HTX-011 (bupivacaine and meloxicam in Biochronomer® polymer technology), a ...
E. Viscusi, H. Minkowitz, P. Winkle, Sonia L. Ramamoorthy, J. Hu, N. Singla   +5 more
semanticscholar   +1 more source

Isoprenalin enhances bupivacaine induced ROS production in freshly isolated cardiomyocytes.

, 2018
Saline group: cells incubated in normal saline. Bupivacaine group: cells incubated with 8.9 μmol/L or 13.3 μmol/L of bupivacaine. Bupivacaine + isoprenalin group: cells incubated with bupivacaine and 5.0 nmol/L of isoprenalin. Bupivacaine + isoprenalin +
Li Chu (459196), Jun Li (6494), Yongxue Chen (5807147), Senming Zhao (357417), Yingying Zhang (42910), Xin Zhao (71840), Jinge Yuan (5807150), Yanxin Cheng (5807144), Hong Li (20183), Dengyun Xia (5807153), Ran Duan (821258), Jianping Zhang (161794)   +11 more
core   +1 more source

Enhancing cognitive processing therapy via stellate ganglion blocks: A pilot randomized trial

Journal of Traumatic Stress, EarlyView.
Abstract Although trauma‐focused psychotherapies, such as cognitive processing therapy (CPT), are effective treatments for posttraumatic stress disorder (PTSD), a substantial portion of individuals exhibit a diminished response. Stellate ganglion block (SGB), an anesthetic procedure targeting the sympathetic nervous system, has shown promise for PTSD ...
Philip Held, Sarah A. Pridgen, Dale L. Smith, Daniel R. Szoke, Asokumar Buvanendran, Robert J. McCarthy   +5 more
wiley   +1 more source

Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice

BMC Veterinary Research, 2020
Background Long-acting local anaesthetics (e.g. bupivacaine hydrochloride) or sustained-release formulations of bupivacaine (e.g. liposomal bupivacaine) may be neurotoxic when applied in the setting of diabetic neuropathy.
Liljana Markova, Nejc Umek, Simon Horvat, Admir Hadžić, Max Kuroda, Tatjana Stopar Pintarič, Vesna Mrak, Erika Cvetko   +7 more
doaj   +1 more source

Ultrasound‐Guided Thoracic Paravertebral Block With Liposomal Versus Standard Bupivacaine for Older Patients After Thoracoscopic Surgery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The study aimed to investigate the effect of thoracic paravertebral block (TPVB) with liposomal bupivacaine (LB) before anesthesia induction on postoperative pain, quality of recovery (QoR), and opioid consumption in older patients after video‐assisted thoracoscopic surgery (VATS).
Wen‐Cheng Shi, Ying‐Jie Tang, Yao Wang, Zhong Zheng, Jing He   +4 more
wiley   +1 more source

Analgesia Quality and Duration of Fentanyl and Sufentanil Added to Bupivacaine in Spinal Anesthesia in Inguinal Hernia Surgery: A Double‐Blind Parallel Randomized Controlled Trial

Health Science Reports
Background and Aims To compare the quality and duration of analgesia provided by Fentanyl and Sufentanil when added to 12–15 mg Bupivacaine 0.5% in spinal anesthesia for inguinal hernia surgery.
Haniyeh Soleimany, Hamed Tavan, Ebrahim Khalighi, Reza Pakzad   +3 more
doaj   +1 more source

Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells

BMC Neuroscience, 2012
Background Bupivacaine-induced neurotoxicity has been shown to occur through apoptosis. Recently, bupivacaine was shown to elicit reactive oxygen species (ROS) production and induce apoptosis accompanied by activation of p38 mitogen-activated protein ...
Harato Misako, Huang Lei, Kondo Fumio, Tsunekawa Koji, Feng Guo-Gang, Fan Jun-Hua, Ishikawa Naohisa, Fujiwara Yoshihiro, Okada Shoshiro   +8 more
doaj   +1 more source

Efficacy of dexamethasone as an adjuvant to bupivacaine in supraclavicular brachial plexus block

Journal of Gandaki Medical College, 2022
Introduction: Supraclavicular brachial plexus block provides the optimal operating conditions for upper arm surgery. The study was conducted to assess the efficacy of dexamethasone as an adjuvant to bupivacaine in supraclavicular brachial plexus block.
Sagun Ram Vaidya, Sandeep Neupane, Kundu Shrestha, Tumaya Ghale   +3 more
doaj   +1 more source