Results 71 to 80 of about 81,525 (242)

Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome [PDF]

, 2017
No abstract ...
Allocco, Bier, Desai, Dryden, Gibson, Hodgson, Jones, Kocherlakota, Liu, Mactier, Maeda, McGlone, McGlone, Noormohammadi, Steinhorn, Yuan   +15 more
core   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Buprenorphine, oxycodone, hydrocodone, and methadone mortality in the United States (2010‒2017)

Journal of the American College of Emergency Physicians Open
Objective Opioid overdose survivors present to emergency departments (EDs) and many EDs have developed programs to initiate buprenorphine. The impact of the increasing use of buprenorphine in ED and by other providers is unknown while opioid mortality ...
Karilynn M. Rockhill, Gabrielle E. Bau, Angela DeVeaugh‐Geiss, Howard Chilcoat, Richard Dart, Janetta Iwanicki, Joshua C. Black   +6 more
doaj   +1 more source

Non‐Invasive Multidimensional Capacitive Sensing for In Vivo Traumatic Brain Injury Monitoring

Advanced Materials Technologies, EarlyView.
Single‐electrode, multidimensional capacitive sensors noninvasively assess cerebral autoregulation and compliance for traumatic brain injury monitoring. ABSTRACT Traumatic brain injury (TBI) is a major cause of death and disability, but invasive intracranial pressure (ICP) monitoring is risky, and current non‐invasive methods lack the resolution and ...
Shawn Kim, Yu‐Jen Cheng, Tianyi Li, Nathan White, Xu Wang, Kristyn Ringgold, Lauren Neidig, Younghoon Kwon, Jae‐Hyun Chung   +8 more
wiley   +1 more source

Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome. [PDF]

, 2011
AIMS: More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) of severity to require pharmacological therapy. Current treatments are associated with prolonged hospitalization.
Abdel-Latif, Agthe, American Academy of Pediatrics Committee on Drugs, Blaser, Coghlan, Colombini, Coyle, Crocetti, Dryden, Dysart, Finnegan, Jackson, Jansson, Johnson, Jones, Kraft, Lainwala, Langenfeld, Mamelle, Nandakumar, O'Grady, Oei, Osborn, Osborn, Sarkar, Seligman, Sutton   +26 more
core   +2 more sources

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Analgesic efficacy of orally administered\ud buprenorphine in rats: methodologic\ud considerations [PDF]

, 2004
Buprenorphine has been widely recommended for treatment of pain in rodents. We have previously documented that the recommended postoperative oral dose of buprenorphine in male Long-Evans rats, 0.5 mg/kg, is not as effective as the recommended parenteral ...
Acheson, Mr. Ashley, Kristal, Dr. Mark B., Martin, Dr. Lisa B.E., Martin, Dr. Thomas, Sallaj, Mr. Abdullah, Thompson, Dr. Alexis C.   +5 more
core  

Evaluating the impact of a national naloxone programme on ambulance attendance at overdose incidents: a controlled time-series analysis [PDF]

, 2017
Background and Aims: It has been suggested that distributing naloxone to people who inject drugs (PWID) will lead to fewer attendances by emergency medical services at opioid-related overdose incidents if peer administration of naloxone was perceived ...
Ashworth, Becketti, Bennett, Bird, Box, Clark, Craig, Darke, Darke, Davoli, Jarosz, Knowlton, Lankenau, Lenton, Longo, McAuley, McAuley, McCain, Merchant, Merrall, Moore, Salmon, Seal, Shermann, Sporer, Strang, Walley, Weatherburn, World Health Organization (WHO), Wright   +29 more
core   +2 more sources