Phage therapy to treat cystic fibrosis Burkholderia cepacia complex lung infections: perspectives and challenges [PDF]
Frontiers in MicrobiologyBurkholderia cepacia complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortality.
Jack S. Canning +11 more
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Virulence, 2021 We recently described a protein O-glycosylation pathway conserved in all species of the Burkholderia genus that results in the synthesis and incorporation of a trisaccharide glycan to membrane-exported proteins.
Guanbo Wang +6 more
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Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health. [PDF]
Vet Med SciThis review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Kanani Y, Oryan A, Derakhshandeh A.
europepmc +2 more sources
Burkholderia stabilis infections associated with contamination of non-sterile alcohol-free skin cleansing wipes, United Kingdom, 2018 to 2026 [PDF]
EurosurveillanceA Burkholderia stabilis (ST480) outbreak associated with skin cleansing wipes has comprised 59 confirmed cases in the United Kingdom 2018–2026. Cases included patients with co-morbidities and clinically relevant infections. There was one associated death.
James Elston
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Prosthetic Joint Infection due to Burkholderia cenocepacia: An Opportunistic Pathogen Microbiology Section with an Expanding Spectrum of Disease [PDF]
Journal of Clinical and Diagnostic Research, 2017 Burkholderia cenocepacia is an opportunistic pathogen widespread in moist environments. It has been associated with lung infections, blood, skin and genitourinary tract infections.
Sujeesh Sebastian +4 more
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Host-pathogen interactions between Burkholderia species and lung epithelial cells [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp.
Jonathan eDavid +3 more
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Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]
, 2017 Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Brackman, Gilles +10 more
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Frontiers in Cellular and Infection Microbiology, 2021 The genus Burkholderia contains over 80 different Gram-negative species including both plant and human pathogens, the latter of which can be classified into one of two groups: the Burkholderia pseudomallei complex (Bpc) or the Burkholderia cepacia ...
Irum Syed, R. Mark Wooten
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Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines
Cells, 2021 Increasing antimicrobial resistance due to misuse and overuse of antimicrobials, as well as a lack of new and innovative antibiotics in development has become an alarming global threat.
Megan E. Grund +4 more
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Current Advances in Burkholderia Vaccines Development
Cells, 2020 The genus Burkholderia includes a wide range of Gram-negative bacterial species some of which are pathogenic to humans and other vertebrates. The most pathogenic species are Burkholderia mallei, Burkholderia pseudomallei, and the members of the ...
Guanbo Wang +2 more
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