Results 51 to 60 of about 69,937 (307)

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

open access: yesAdvanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu   +7 more
wiley   +1 more source

Letter: Helen Alexander Burr to Ida M. Tarbell, April 14, 1940 [PDF]

open access: yes, 1940
Handwritten letter about book reviews, one being Lincoln and the ...
Burr, Helen Alexander
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

open access: yesAdvanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu   +12 more
wiley   +1 more source

Research progress on exit burr in drilling assembly hole of aerospace aluminum alloy components

open access: yesJin'gangshi yu moliao moju gongcheng, 2022
There is a large demand for aluminum alloy assembly hole machining in aerospace manufacturing industry. The assembly hole is mainly realized by drilling, and there is a problem that the aluminum alloy exit burr is too large in the processing.
Xiaoshi WANG   +3 more
doaj   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

open access: yesAdvanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian   +12 more
wiley   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

open access: yesAdvanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo   +10 more
wiley   +1 more source

Prediction of thickness and height of burr based on burr formation mechanisms in end milling

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
Edge imperfections are often introduced on workpieces due to plastic deformation during machining. These imperfections are known as burrs. Since the deburring operation is costly, the control of burr formation is a research topic of great significance ...
Sothea KRUY   +3 more
doaj   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan   +9 more
wiley   +1 more source

Melissa Burr Interview [PDF]

open access: yes, 2019
This interview is an oral history conducted by Linfield College archivist Rich Schmidt with Melissa Burr of Stoller Family Estate. The interview took place at Stoller Family Estate in Dayton, Oregon on January 24, 2019.
Burr, Melissa
core  

Data for: A history of the modern Aral Sea (Central Asia) since the Late Pleistocene [PDF]

open access: yes
Radiocarbon dates from a sediment core drilled from the Aral Sea discussed by Burr et al. (2018)
Burr, G
core   +1 more source

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