BMC Pharmacology and Toxicology, 2022 Background Administration of antineoplastic drugs may cause azoospermia driving to subfertility. Production of animal azoospermia models is essential for evaluating new treatment methods before therapeutic interventions in human setup.
Halimeh Mobarak +4 more
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A Clinically Relevant Drug Interaction Between Busulfan and Rifampin in the Setting of Hematopoietic Stem Cell Transplant Conditioning [PDF]
Pharmacology Research & PerspectivesBusulfan is an alkylating agent used in combination with other chemotherapeutic agents and has become a common component of conditioning regimens prior to hematopoietic stem cell transplantation. Busulfan has a very narrow therapeutic index corresponding
Colleen Drangines +2 more
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Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment [PDF]
BiologyStromal vascular fraction (SVF), an uncultured adipose-derived cell population, exerts regenerative effects primarily through paracrine mechanisms.
Tiantian Li +7 more
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Efficacy and safety of Busulfan–Fludarabine versus Busulfan–Cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplant in hematologic malignancy patients: a meta-analysis of randomized controlled trials and observational studies [PDF]
Therapeutic Advances in HematologyBackground: Conditioning regimen selection significantly impacts the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies.
Aizaz Ali +17 more
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Pharmaceuticals, 2021 Busulfan has been used as a conditioning regimen in allogeneic hematopoietic cell stem transplantation (HSCT). Owing to a large inter-individual variation in pharmacokinetics, therapeutic drug monitoring (TDM)-guided busulfan dosing is necessary to ...
Rong-Long Chen +6 more
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Frontiers in Pharmacology, 2022 Aims: The aims of the study were to 1) establish a population pharmacokinetic (Pop-PK) model for busulfan in Chinese pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and then estimate busulfan exposure and 2) explore the ...
Xiaohuan Du +22 more
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American Journal of Ophthalmology Case Reports, 2022 Purpose: Myeloproliferative neoplasms (MPNs) have been associated with increased systemic levels of vascular endothelial growth factor (VEGF). This study investigated an association between systemic busulfan for treatment of MPN and the requirement for ...
Lauren A. Dalvin +5 more
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Mesenchymal Stem Cells for Busulfan–Induced Azoospermia: An Experimental Study [PDF]
International Journal of Medical Arts, 2022 Background: Busulfan is a frequently used chemotherapeutic agent. It exerts harmful effects on male reproduction. Azoospermia is a major cause of male infertility, and stem cell therapy may be a reasonable treatment option.The aim of the work: The ...
Fawzy Mahmoud Ali Abougalala +4 more
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Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial Stem Cell Transplantation Is Safe and Non-Toxic. [PDF]
PLoS ONE, 2016 Current methods of administering busulfan to remove the endogenous germ cells cause hematopoietic toxicity, require special instruments and a narrow transplantation time.
YuSheng Qin +9 more
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Pharmaceutics, 2023 Reaching target exposure of busulfan-based conditioning prior to hematopoietic stem cell transplantation is vital for favorable therapy outcomes. Yet, a wide inter-patient and inter-occasion variability in busulfan exposure has been reported, especially ...
Katharina M. Schreib +6 more
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