Results 11 to 20 of about 18,506 (177)

Proteomic analysis for busulfan-induced spermatogenesis disorder

Annals of Medicine
Background Busulfan is the most commonly used drug for the treatment of chronic myelogenous leukemia and pretreatment for hematopoietic stem cell transplantation, which can damage the reproductive and immune system.
Ke Hu, Qinran Zhu, Jiaqi Zou, Xin Li, Min Ye, Jing Yang, Sixieyang Chen, Fan Li, Biao Ding, Shuai Yang, Chuanwang Song, Meng Liang   +11 more
doaj   +2 more sources

Effects of Perilla frutescens Var. Acuta in Busulfan-Induced Spermatogenesis Dysfunction Mouse Model

The World Journal of Men's Health
Purpose: The leaves of Perilla frutescens var. acuta (PFA) are generally reported to have antioxidant, anti-allergic, anti-inflammatory, and antitumor effects and commonly used as a traditional medicine in East Asia. This study aimed to investigate the
Hyung Jong Nam, Min Jung Park, Bo Sun Joo, Yean Kyoung Koo, SukJin Kim, Sang Don Lee, Hyun Jun Park   +6 more
doaj   +2 more sources

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation. [PDF]

Adv Sci (Weinh)
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Y, Yu L, Zhang W, Wessel G, Chen R, Hu W, Xu D.   +6 more
europepmc   +2 more sources

Comparison of Melphalan Combined with Treosulfan or Busulfan as High-Dose Chemotherapy before Autologous Stem Cell Transplantation in AML. [PDF]

, 2022
(1) Background: High-dose chemotherapy (HDCT) before autologous stem cell transplantation (ASCT) in acute myeloid leukemia (AML) patients predominantly combines busulfan with cyclophosphamide or melphalan.
Michael Hayoz, Aebi, Yolanda, Largiadèr, Carlo R, Pabst, Thomas, Yolanda Aebi, Thomas Pabst, Mansouri Taleghani, Behrouz, Ulrike Bacher, Hayoz, Michael, Ekaterina Gurevich, Gurevich, Ekaterina, Carlo R. Largiadèr, Bacher, Ulrike, Behrouz Mansouri Taleghani   +13 more
core   +2 more sources

Effects of Bene (Pistacia atlantica) on Histopathology of Testis, Sperm Chromatin Quality and Stress Oxidative in Busulfan-Induced Infertile Mice [PDF]

Pharmaceutical Sciences, 2019
Background: Some plants stimulate spermatogenesis and increase fertility, while some cause spermatogenesis arrest. So far, the effects of bene (Pistacia atlantica) on male fertility have not been studied.
Hojat Norasteh, Shabnam Mohammadi, Mohammad Reza Nikravesh, Samaneh Broumand, Farimah Beheshti   +4 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques

Molecular Therapy: Methods & Clinical Development, 2023
The clonal dynamics following hematopoietic stem progenitor cell (HSPC) transplantation with busulfan conditioning are of great interest to the development of HSPC gene therapies.
Diana M. Abraham, Richard J. Lozano, Xavi Guitart, Jialiu A. Liang, Ryland D. Mortlock, Diego A. Espinoza, Xing Fan, Allen Krouse, Aylin Bonifacino, So Gun Hong, Komudi Singh, John F. Tisdale, Chuanfeng Wu, Cynthia E. Dunbar   +13 more
doaj   +1 more source

Pulmonary hypertension associated with busulfan

, 2021
Busulfan is widely used to treat malignant diseases, particularly for therapeutic intensification prior to an autologous stem cell graft. Numerous side effects consecutive to busulfan are described, but few descriptions of pulmonary hypertension exist ...
Ghigna, Maria‐rosa, Marie‐Camille Chaumais, Hagenburg, Jean, Humbert, Marc, Chaumais, Marie‐camille, Sitbon, Olivier, Montani, David, Xavier Jaïs, Benoit Lechartier, Lechartier, Benoit, Maria‐Rosa Ghigna, Savale, Laurent, Marc Humbert, Jaïs, Xavier, Olivier Sitbon, Jean Hagenburg, David Montani, Laurent Savale   +17 more
core   +1 more source

Ellagic acid effects on testis, sex hormones, oxidative stress, and apoptosis in the relative sterility rat model following busulfan administration

BMC Complementary Medicine and Therapies, 2022
Background Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to sterility.
Amirabbas Rostami, Sina Vakili, Farhad Koohpeyma, Bahia Namavar Jahromi, Ziba Afshari Aghajari, Fatemeh Mahmoudikohani, Forough Saki, Marzieh Mahmoodi, Khojaste Rahimi Jaberi, Ahmad Movahedpour, Majid Jafari Khorchani, Saam Noroozi   +11 more
doaj   +1 more source

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG-4592). [PDF]

Cell Prolif
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Yang G, Wu J, Guo X, Shen W, Sang X, Gong X, Huang SZ, Zhang J, Zeng F.   +8 more
europepmc   +2 more sources