Results 101 to 110 of about 18,506 (177)

Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation

Frontiers in Pharmacology
BackgroundBusulfan is known for its high inter- and intra-individual pharmacokinetics/pharmacodynamics (PK/PD) variability, especially in children. Therefore, we aimed to identify factors affecting PK variability of busulfan in pediatric allogeneic ...
Di Cao, Xiaowen Qian, Ping Wang, Xinyi Zheng, Shan Huang, Zhonglin Wei, Wenjin Jiang, Ling Yu, Xin Jiang, Ying Yu, Junjun Mao, Xiaowen Zhai   +11 more
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Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assay

, 2017
Purpose. The stability of busulfan solution in 0.9% sodium chloride and stored in polypropylene syringes or infusion bags was evaluated. Methods. Busulfan solutions (0.54 mg/mL) were prepared and transferred to 50-mL polypropylene syringes and 100- and ...
Sandrine Fleury-Souverain, Fleury-Souverain, Sandrine, Serge Rudaz, Pascal Bonnabry, Rudaz, Serge, Bonnabry, Pascal, Nicolas Guichard, Guichard, Nicolas   +7 more
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Molecular reactivity of busulfan through its experimental electrostatic properties in the solid state

, 2004
International audiencePurpose. In the route of developing novel liquid phase formulations based on the encapsulation of busulfan into liposomes in nontoxic solvents, drug crystallization inevitably occurs.
Ghermani, N.E., Ouharzoune, S., Layre, A., Gref, R., Spasojevic - De Biré, Anne, Bouhmaida, N., Bouligand, J., Couvreur, P.   +7 more
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Morbidity and non-relapse mortality after allogeneic bone marrow transplantation in adult leukemia patients conditioned with busulfan plus cyclophosphamide: a retrospective comparison of oral versus intravenous busulfan

Haematologica, 2005
We retrospectively compared morbidity and non-relapse mortality (NRM) after allogeneic bone marrow transplantation (BMT) in 236 adults with leukemia and myelodysplastic syndrome conditioned with cyclophosphamide plus oral versus intravenous busulfan. Our
SE Kim, JH Lee, SJ Choi, JH Lee, SG Ryu, KH Lee   +5 more
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Propolis mitigates busulfan-induced testicular dysfunction in rats: insights into redox stabilization, PCNA modulation, and caspase-3 inhibition

Frontiers in Pharmacology
IntroductionTesticular cytofunctional defects are among the most hazardous effects of cancer chemotherapies. Propolis mitigates the fertility problems associated with gonadotoxic agents through its redox stabilizing, anti-apoptotic, and cytoprotective ...
Elham A. AbdAllah, Basant A. Eid, Hassan A. Hussein, Hassan A. Hussein, Nasser S. Abou khalil, Nasser S. Abou khalil, Sohair M. M. Ragab, Asmaa Y. Wahman, Hailah M. Almohaimeed, Rehab H. Moneeb, Hanem S. Abdel-Tawab, Zuhair M. Mohammedsaleh, Jameel Barnawi, Hanan S. A. Waly   +13 more
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Therapeutic drug monitoring of busulfan in pediatric patients: a 5-year observational study

BMC Pharmacology and Toxicology
Background Busulfan is a chemotherapeutic agent used in conditioning regimens before hematopoietic stem cell transplantation (HSCT) in pediatric patients.
Nedaa Alomari, Amani Kurdi, Meshari Alghamdi, Waleed Alhussaini, Ghanem Ezzeldeen, Eman Alharbi, Alaa Aldahri, Imadul Islam, Mohammed Essa   +8 more
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Busulfan and subsequent malignancy: An evidence-based risk assessment [PDF]

BACKGROUND: The incidence of secondary malignancies associated with busulfan exposure is considered low, but has been poorly characterized. Because this alkylating agent is increasingly utilized as conditioning prior to gene therapy in nonmalignant ...
Long-Boyle, Janel R, Reatz, Meredith, Matos, Joana, Shah, Arpita, Sevilla, Julian, Booth, Claire, Spencer, Sueli Marques, Nicoletti, Eileen, Schwartz, Jonathan D, Lorenzo, Jose Luis Lopez, Kohn, Donald B, Shah, Ami J   +11 more
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Cyclophosphamide-Busulfan Instead of Busulfan-Cyclophosphamide for Conditioning in Allogeneic Hematopoietic Stem Cell Transplantation.

Abstract 2268 Poster Board II-245 Busulfan-cyclophosphamide (BU-CY) is the established non total body irradiation based myeloablative conditioning regimen for allogeneic hematopoietic ...
Cantoni, Nathan, Bucher, Christoph, Rovo, Alicia, Gratwohl, Alois, Tichelli, Andre, Buser, Andreas S., Stern, Martin, Gerull, Sabine, Halter, Joerg, Heim, Dominik, Tsakiris, Dimitrios, Arber, Caroline, Passweg, Jakob R.   +12 more
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Optimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times

Drug Design, Development and Therapy
Yun Kim,1 Sungha Moon,2 Su-Jin Rhee2 1College of Pharmacy, Daegu Catholic University, Gyeongsan, 38430, Republic of Korea; 2College of Pharmacy, Wonkwang University, Iksan, 54538, Republic of KoreaCorrespondence: Su-Jin Rhee, College of Pharmacy ...
Kim Y, Moon S, Rhee SJ
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Protective Effect of Crocin on Histomorphometry Growth and Atresia of Ovarian Follicles among Laboratory Rats treated with Busulfan

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019
Introduction: Busulfan-related oxidative stress reduces fertility; therefore, this study aimed to investigate the protective role of crocin on ovarian histological changes.   Materials & Methods: This study was conducted on 30 adult NMRI rats weighing 22-
Hamidreza Hassanzadeh khanmiri, Rasoul Shahrooz, Shapour Hassanzadeh, Gholamreza Najafi   +3 more
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