Brugia Malayi: Depletion of Glutathione by Buthionine Sulfoximine [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2005 Glutathione is an intracellular reducing agent. It is synthesized by a two-step reaction catalyzed by ?-glutamylcysteine synthetase (?GCS) and glutathione synthetase.
Ayman Hussein
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The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO) [PDF]
BMC Neuroscience, 2005 Background glutathione (GSH) is the most abundant thiol antioxidant in mammalian cells. It directly reacts with reactive oxygen species (ROS), functions as a cofactor of antioxidant enzymes, and maintains thiol redox potential in cells. GSH depletion has
Berry Marla J +3 more
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Retraction: Synergistic Apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. [PDF]
PLoS OnePLOS One Editors.
europepmc +2 more sources
Glutathione metabolism-linked ferroptosis in human seminoma: a spatial multi-omics mapping study. [PDF]
Redox BiolTesticular cancer is the most common solid tumor in young men aged 15-44 years, with seminoma being a major subtype. To elucidate its poorly understood molecular mechanisms, we performed integrated spatial transcriptomics (ST) and spatial metabolomics ...
Deng C +16 more
europepmc +2 more sources
Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis [PDF]
Free Radical Biology and Medicine, 2004 Treatment with the anticancer drug cyclophosphamide (CPA) destroys ovarian follicles. The active metabolites of CPA are detoxified by conjugation with glutathione (GSH). We tested the hypotheses that CPA causes apoptosis in ovarian follicles and that suppression of ovarian GSH synthesis before CPA administration enhances CPA-induced apoptosis ...
Lopez, Sarah G, Luderer, Ulrike
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Preclinical Evaluation of Azathioprine Plus Buthionine Sulfoximine in the Treatment of Human Hepatocarcinoma and Colon Carcinoma [PDF]
World Journal of Gastroenterology, 2011 Eva P Cuevas +2 more
exaly +2 more sources
A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
Communications Chemistry, 2022 Platinum(IV) complexes have the potential to overcome several limitations and reduce adverse effects of platinum-based cancer therapy. Resistance to clinically approved platinum(II) drugs is, at least in part, associated with elevated levels of ...
Philipp Fronik +9 more
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Cardiovascular and renal manifestations of glutathione depletion induced by buthionine sulfoximine [PDF]
American Journal of Hypertension, 2012 Oxidative stress contributes to the development of several cardiovascular diseases, including diabetes, renal insufficiency, and arterial hypertension. Animal studies have evidenced the association between higher blood pressure (BP) and increased oxidative stress, and treatment with antioxidants has been shown to reduce BP, while BP reduction due to ...
Vargas, Félix +5 more
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Knockdown of glutamate cysteine ligase catalytic subunit by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells. [PDF]
PLoS ONE, 2015 Gold nanoparticles (GNPs) have shown promising medical applications in cancer treatment involved in the regulation of intracellular redox balance. Previously, we have reported that GNPs can trigger apoptosis and necrosis in human lung cancer cells (A549)
Min Liu, Yunxue Zhao, Xiumei Zhang
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The effect of oxidant and the non-oxidant alteration of cellular thiol concentration on the formation of protein mixed-disulfides in HEK 293 cells. [PDF]
PLoS ONE, 2008 Cellular molecules possess various mechanisms in responding to oxidant stress. In terms of protein responses, protein S-glutathionylation is a unique post-translational modification of protein reactive cysteines forming disulfides with glutathione ...
Jasen Lee Gilge +2 more
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