Results 21 to 30 of about 6,620 (168)

Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice [PDF]

Carcinogenesis, 2005
Oxidative stress and genomic rearrangements play a role in cancer development. l-Buthionine-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting gamma-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH).
Ramune, Reliene, Robert H, Schiestl
openaire   +2 more sources

Effect of ochratoxin A and buthionine sulfoximine on proteome and ascorbate-glutathione cycle enzymes in Arabidopsis thaliana

Biologia Plantarum, 2015
In this study, proteome and activities of glutathione (GSH)-related enzymes were investigated in detached leaves of Arabidopsis thaliana treated with ochratoxin A (OTA) alone or supplemented with buthionine sulfoximine (BSO, a specific inhibitor of the ...
J. R. Hao, Y. Wang, W. W. Zhao, W. T. Xu, Y. B. Luo, Z. J. Yang, W. H. Wu, Z. H. Liang, K. L. Huang   +8 more
doaj   +1 more source

The effect of buthionine sulfoximine on the growth ofLeishmania donovaniin culture [PDF]

FEMS Microbiology Letters, 1999
Changes in composition of the principal low molecular mass thiols of Leishmania donovani were monitored during the transformation of promastigotes, first to stationary phase metacyclic forms and then to amastigotes. No consistent variation in the thiol composition of the parasite which could account for the known increase in resistance of metacyclic ...
D P, Weldrick, B, Chodacka, R, Vogt, D J, Steenkamp   +3 more
openaire   +3 more sources

Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and γ-Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum

Frontiers in Cellular Neuroscience, 2019
Glutathione (GSH) is the most abundant intracellular antioxidant. GSH depletion leads to oxidative stress and neuronal damage in the central nervous system (CNS).
Cesar Valdovinos-Flores, Jorge H. Limón-Pacheco, Renato León-Rodríguez, Pavel Petrosyan, Carla Garza-Lombó, Maria E. Gonsebatt   +5 more
doaj   +1 more source

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

eLife, 2021
Chemotherapy resistance is a critical barrier in cancer treatment. Metabolic adaptations have been shown to fuel therapy resistance; however, little is known regarding the generality of these changes and whether specific therapies elicit unique metabolic
Shawn McGuirk, Yannick Audet-Delage, Matthew G Annis, Yibo Xue, Mathieu Vernier, Kaiqiong Zhao, Catherine St-Louis, Lucía Minarrieta, David A Patten, Geneviève Morin, Celia MT Greenwood, Vincent Giguère, Sidong Huang, Peter M Siegel, Julie St-Pierre   +14 more
doaj   +1 more source

Buthionine Sulfoximine Increases the Toxicity of Nifurtimox and Benznidazole toTrypanosoma cruzi [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACTl-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward the epimastigote, trypomastigote, and amastigote forms ofTrypanosoma cruzi. BSO at 500 μM decreased total glutathione-derived thiols by 70 to 80% in 48 h.
Faúndez Cáceres, Mario, Pino, L., Letelier, P., Ortiz, C., Lopez, R., Seguel, C., Ferreira, J., Pavani, M., Morello, A., Maya, J.D.   +9 more
openaire   +5 more sources

ReactELISA method for quantifying methylglyoxal levels in plasma and cell cultures

Redox Biology, 2019
Methylglyoxal (MG) is a toxic glycolytic by-product associated with increased levels of inflammation and oxidative stress and has been linked to ageing-related diseases, such as diabetes and Alzheimer's disease.
Rasmus Kold-Christensen, Karina Kragh Jensen, Emil Smedegård-Holmquist, Lambert Kristiansen Sørensen, Jakob Hansen, Karl Anker Jørgensen, Peter Kristensen, Mogens Johannsen   +7 more
doaj   +1 more source

Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

Cancer Cell International, 2005
Background Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet, though glutathione (GSH) is ...
Savas Burhan, Akca Hakan, Akan Selma, Akan Ilhan, Ozben Tomris   +4 more
doaj   +1 more source

Biosynthesis of Gold Nanoparticles by Vascular Cells in vitro

Frontiers in Microbiology, 2022
Biosynthesis of gold nanoparticles (AuNPs) for antimicrobial and chemotherapeutic applications is a well-established process in microbial hosts such as bacterial, fungi, and plants. However, reports on AuNPs biosynthesis in mammalian cells are scarce. In
Michael Kitching, Michael Kitching, Saikumar Inguva, Meghana Ramani, Yina Gao, Enrico Marsili, Paul Cahill   +6 more
doaj   +1 more source

Application of exogenous glutathione decreases chromium translocation and alleviates its toxicity in soybean (Glycine max L.)

Ecotoxicology and Environmental Safety, 2022
Chromium is considered one of the most severe toxic elements affecting agriculture. Soybean seedlings under chromium stress were treated with glutathione and buthionine sulfoximine. The effects of exogenous glutathione on the physiological effects of two
Ke Wen, Xingang Li, Rong Huang, Hai Nian
doaj   +1 more source