Results 71 to 80 of about 6,620 (168)

Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia

Neurobiology of Disease, 2004
Schizophrenia is associated with a cerebral glutathione deficit, which may leave the brain susceptible to oxidants. To study the consequences of a glutathione deficit, we treated developing rats with l-buthionine-(S,R)-sulfoximine (BSO), an inhibitor of ...
Vincent Castagné, Michaël Rougemont, Michel Cuenod, Kim Q Do   +3 more
doaj   +1 more source

Targeting Oxidative Stress With Auranofin or Prima-1Met to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells

Frontiers in Oncology, 2019
Prima-1Met (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53.
Benoit Tessoulin, Benoit Tessoulin, Benoit Tessoulin, Benoit Tessoulin, Geraldine Descamps, Geraldine Descamps, Geraldine Descamps, Christelle Dousset, Christelle Dousset, Christelle Dousset, Martine Amiot, Martine Amiot, Martine Amiot, Catherine Pellat-Deceunynck, Catherine Pellat-Deceunynck, Catherine Pellat-Deceunynck   +15 more
doaj   +1 more source

Disturbing the Redox Balance Using Buthionine Sulfoximine Radiosensitized Somatostatin Receptor-2 Expressing Pre-Clinical Models to Peptide Receptor Radionuclide Therapy with ¹⁷⁷Lu-DOTATATE. [PDF]

Cancers (Basel), 2023
Delbart W, Marin G, Stamatopoulos B, de Wind R, Sirtaine N, Demetter P, Vercruyssen M, Woff E, Karfis I, Ghanem GE, Flamen P, Wimana Z.   +11 more
europepmc   +1 more source

8-Epidiosbulbin E acetate triggers apoptosis via metabolic activation-mediated crosstalk between mitochondria and endoplasmic reticulum

Ecotoxicology and Environmental Safety
8-Epidiosbulbin E acetate (EEA), a furan-containing diterpenoid lactone and key component of Dioscorea bulbifera L., has been found to induce notable liver injury in mice through CYP3A-mediated metabolic activation to a cis-enedial reactive metabolite ...
Shiyu Zhang, Bowen Gong, Rong Tan, Yufen Liao, Xin Wang, Xu Wang, Ying Liu, Ting Liu, Jun Luo, Weiwei Li, Jia Yu, Ying Peng, Jiang Zheng   +12 more
doaj   +1 more source

Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response

Redox Biology
Lung cancer cells are vulnerable to iron-dependent oxidation of phospholipids leading to ferroptosis, a process countered by glutathione peroxidase-4 that converts lipid hydroperoxides to lipid alcohols using glutathione as reducing agent.
Viktor Antonsson Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha W. Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, Andreas Persson, Fikret Zahirovic, Clotilde Wiel, Volkan I. Sayin, Per Lindahl   +14 more
doaj   +1 more source

Natural combination of phenolic glycosides from fruits resists pro-oxidant insults to colon cells and enhances intrinsic antioxidant status in mice

Toxicology Reports, 2019
A combination of fresh fruits adequately supplying required nutrients is likely to have better health benefits by virtue of the synergistic/additive effect of its natural constituents.
Soorya Parathodi Illam, Ashif Hussain, Anu Elizabeth, Arunaksharan Narayanankutty, Achuthan C. Raghavamenon   +4 more
doaj   +1 more source

Buthionine Sulfoximine [PDF]

, 2020
openaire   +1 more source

Comparative Study of Injected Alzheimer’s Disease Models in Rats: Insights from Experimental Research

Pathophysiology
Background/Objectives: Alzheimer’s disease (AD) remains incurable, highlighting the need for new and diverse animal models to better understand its complex mechanisms.
Hanane Doumar, Hicham El Mostafi, Aboubaker Elhessni, Abderrahim Laaziz, Abdelhalem Mesfioui   +4 more
doaj   +1 more source

Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]

Sci Rep, 2016
Du M, Zhang L, Scorsone KA, Woodfield SE, Zage PE.   +4 more
europepmc   +1 more source

Protective Effect of Tempol on Buthionine Sulfoximine-Induced Mitochondrial Impairment in Hippocampal Derived HT22 Cells. [PDF]

Oxid Med Cell Longev, 2016
Salvi A, Patki G, Khan E, Asghar M, Salim S.   +4 more
europepmc   +1 more source