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Butylated Hydroxyanisole in Perspective
Butylated hydroxyanisole (BHA) is a synthetic food antioxidant used to prevent oils, fats and shortenings from oxidative deterioration and rancidity. This review depicts the current knowledge on BHA. The physical and chemical characteristics of BHA are summarized and its function as a food antioxidant is made clear. The toxicological characteristics of
Hans Verhagen, J C Kleinjans
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Free Radical Research Communications, 1992
The widely used food additives butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) react with oxyhemoglobin, thereby forming methemoglobin. The reaction rates were measured using visible spectroscopy, and second order rate constants were established for BHA and compared with p-hydroxyanisole.
Hans Nohl, Klaus Stolze, H Nohl
exaly +3 more sources
The widely used food additives butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) react with oxyhemoglobin, thereby forming methemoglobin. The reaction rates were measured using visible spectroscopy, and second order rate constants were established for BHA and compared with p-hydroxyanisole.
Hans Nohl, Klaus Stolze, H Nohl
exaly +3 more sources
A study of the teratogenicity of butylated hydroxyanisole on rabbits
A teratogenicity study on butylated hydroxyanisole (BHA) was carried out in SPF New Zealand White rabbits. BHA was given by gavage from day 7--18 of the gestation period in doses of 0, 50, 200 and 400 mg/kg body wt./day. The fetuses were removed on day 28.
E, Hansen, O, Meyer
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Comparative Pharmacokinetics of Butylated Hydroxyanisole and Butylated Hydroxytoluene in Rabbits
Journal of Pharmaceutical Sciences, 1980The widespread use of butylated hydroxyanisole (I) and butylated hydroxytoluene (II) as food antioxidants recently has been criticized by the Food and Drug Administration because of their pharmacological and toxicological effects. Interest also has arisen recently in the use of these compounds as anticancer agents.
Sarfaraz Khan Niazi
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Interaction of butylated hydroxyanisole with mitochondrial oxidative phosphorylation
The antioxidant, butylated hydroxyanisole (BHA), has a number of effects on mitochondrial oxidative phosphorylation. In this study we apply the novel approach developed by Brand (Brand MD, Biochim Biophys Acta 1018: 128-133, 1990) to investigate the site of action of BHA on oxidative phosphorylation in rat liver mitochondria.
Fusi, Fabio +2 more
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Antioxidant Synergism Between Butylated Hydroxyanisole and Butylated Hydroxytoluene
JAOCS, Journal of the American Oil Chemists' Society, 1995AbstractDecay of the 2,6‐di‐tert‐butyl‐4‐methylphenoxy radical [butylated hydroxytoluene (BHT)‐radical] in the presence of butylated hydroxyanisole (BHA) was investigated in 1,2‐dimethoxyethane with or without triethylamine. BHT‐radical was conveniently generated by dissociation of its unstable dimer in solution.
Kanji Omura
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Intake of Butylated Hydroxyanisole and Butylated Hydroxytoluene and Stomach Cancer Risk: Results From Analyses in the Netherlands Cohort Study [PDF]
Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
Hans Verhagen +2 more
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Butylated Hydroxyanisole Isomers Induce Distinct Adipogenesis in 3T3-L1 Cells
Butylated hydroxyanisole (BHA) isomers, as the widely used anthropogenic antioxidants in food, have been revealed to induce endocrine disrupting effects, while the mechanism how BHA isomers regulate the lipogenic differentiation remains to be elucidated.
Jianqing Zhang +2 more
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Bradykinin Inhibition by Butylated Hydroxyanisole
Science, 1970Concentrations of butylated hydroxyanisole as low as 8 × 10 -9 mole per liter can inhibit detectably the contraction of smooth muscle elicited by bradykinin. The mechanism of the inhibitory effect of this food grade anti-oxidant is apparently complex, and the effect is only partially reversible.
L P, Posati, M J, Pallansch
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Effects of butylated hydroxyanisole in Drosophila melanogaster
Mutation Research/Genetic Toxicology, 1976The standard sex-linked recessive lethal test using "Basc" virgin females and treated Canton S males was used to test potential mutagenicity of ingested butylated hydroxyanisole (BHA) on mature spermatozoa. Ethyl methanesulfonate (EMS) was employed as a positive control and at lower concentrations a roughly linear dose response curve resulted.
M P, Miyagi, C R, Goodheart
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