Repeated dosing of myrrh, chamomile extract, and coffee charcoal reveals potential health-beneficial effects in patients with irritable bowel syndrome in the M-SHIME simulator. [PDF]
Wonnemann M +6 more
europepmc +1 more source
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Gut Microbiota and Acute Myeloid Leukemia: State of the Art, Clinical Signals, and Translational Opportunities. [PDF]
Alvaro ME +12 more
europepmc +1 more source
Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova +6 more
wiley +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Butyrate Silences <i>MUC5AC</i> in Airway Epithelial Cells Through Histone Deacetylation at Its Promoter Region. [PDF]
Jo SH +6 more
europepmc +1 more source
Uncovering syntrophic potential from genome-resolved metagenomics of suspended and granular anaerobic digestion sludges. [PDF]
Besteman MS +5 more
europepmc +1 more source
Fine-Gradient Low-Molecular-Weight Hyaluronic Acid Supplementation Modulates Gut Microbial Profiles and SCFA Output in a Starch-Containing In Vitro Fecal Fermentation Model. [PDF]
Dong J +6 more
europepmc +1 more source
Predictive Biomarkers for Sustained Unresponsiveness Following Oral Immunotherapy
Clinical &Experimental Allergy, EarlyView.
Duan Ni, Ralph Nanan
wiley +1 more source

