Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova +6 more
wiley +1 more source
Circulating Butyrate Attenuates Cetuximab Efficacy in Colorectal Cancer Through EGFR and AMPK-Wip1 Signaling. [PDF]
Zhang J +9 more
europepmc +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Gut microbial metabolites, barrier dysfunction, and endotoxemia in men obstructive sleep apnea-associated hypertension. [PDF]
Ko CY, Zhang L, Lin Y, Zeng Y.
europepmc +1 more source
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen +9 more
wiley +1 more source
Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming. [PDF]
Liu J +5 more
europepmc +1 more source
Predictive Biomarkers for Sustained Unresponsiveness Following Oral Immunotherapy
Clinical &Experimental Allergy, EarlyView.
Duan Ni, Ralph Nanan
wiley +1 more source
ABSTRACT Climate change has intensified the need to reduce greenhouse gas emissions, particularly methane (CH4) from enteric fermentation. Genetic selection has emerged as a promising mitigation strategy; however, studies on Bos taurus indicus , especially Nellore cattle, remain limited.
J. A. Silva +10 more
wiley +1 more source
Short-Chain Fatty Acids Elicit Differential Expression of Growth Factors and Pro-Inflammatory Cytokines in Immortalized Rat Enteric Glial Cells. [PDF]
Beltran MM, Defries DM.
europepmc +1 more source

