Results 41 to 50 of about 302,602 (263)

G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1

iScience
Summary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault, François Bolduc, Marc-Antoine Turcotte, Jean Pierre Perreault   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A conceptual mechanistic model of amino acid fluxes in the small intestine, taking the example of pig

Animal
During digestion, almost 50% of absorbed essential amino acids (AAs) are metabolised by intestinal tissue, thus not appearing directly in the portal vein.
C.J.J. Garçon, N. Le Floc’h, Y. Mercier, J. van Milgen   +3 more
doaj   +1 more source

Study of hepatic binding protein activity in jejuno‐ileal by‐passed rat hepatocytes [PDF]

FEBS Letters, 1985
The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno‐ileal by‐passed rat hepatocytes. In by‐passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3‐fold, without any modification of apparant constant of internalization.
Serbource-Goguel, Nathalie, Dodeur, Michèle, Borel, Béatrice, Feger, Jeanne, Agneray, Jean, Durand, Geneviève   +5 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Productive response of dairy cows to a supplementation with methionine hydroxy analog

Italian Journal of Animal Science, 2011
Methionine and lysine have been identified most frequently as first-limiting essential amino acids in the protein nutrition of dairy cattle (NRC, 2001).
I. Andrighetto, S. Segato, P. Berzaghi, G. Cozzi   +3 more
doaj   +1 more source

De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features. [PDF]

PLoS ONE, 2008
Function prediction frequently relies on comparing genes or gene products to search for relevant similarities. Because the number of protein structures with unknown function is mushrooming, however, we asked here whether such comparisons could be ...
R Matthew Ward, Serkan Erdin, Tuan A Tran, David M Kristensen, Andreas Martin Lisewski, Olivier Lichtarge   +5 more
doaj   +1 more source

A message passing approach to Side Chain Positioning with applications in protein docking refinement [PDF]

2012 IEEE 51st IEEE Conference on Decision and Control (CDC), 2012
We introduce a message-passing algorithm to solve the Side Chain Positioning (SCP) problem. SCP is a crucial component of protein docking refinement, which is a key step of an important class of problems in computational structural biology called protein docking.
Mohammad Moghadasi, Dima Kozakov, Artem B. Mamonov, Pirooz Vakili, Sandor Vajda, Ioannis Ch. Paschalidis   +5 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection

Cell Reports, 2019
Summary: Although flaviviruses co-opt the function of the host endoplasmic reticulum (ER) membrane protein complex (EMC) during infection, a mechanistic explanation for this observation remains unclear.
David L. Lin, Takamasa Inoue, Yu-Jie Chen, Aaron Chang, Billy Tsai, Andrew W. Tai   +5 more
doaj   +1 more source