Results 41 to 50 of about 60,574,786 (305)
G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1
iScienceSummary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault +3 more
doaj +1 more source
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins
BMC Genomics, 2019 Background Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments.
Tommaso Orioli, Mauno Vihinen
doaj +1 more source
Na+/Ca2+ selectivity in the bacterial voltage-gated sodium channel NavAb [PDF]
PeerJ, 2013 The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated.
Ben Corry
doaj +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Membranome: a database for proteome-wide analysis of single-pass membrane proteins [PDF]
Nucleic Acids Research, 2016 The Membranome database was developed to assist analysis and computational modeling of single-pass (bitopic) transmembrane (TM) proteins and their complexes by providing structural information about these proteins on a genomic scale. The database currently collects data on >6000 bitopic proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium ...
Andrei L. Lomize +3 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
AnimalDuring digestion, almost 50% of absorbed essential amino acids (AAs) are metabolised by intestinal tissue, thus not appearing directly in the portal vein.
C.J.J. Garçon +3 more
doaj +1 more source
Dose dependent toxicity of glutamic acid: a review
International Journal of Food Properties, 2020 L-glutamate, the major neurotransmitter in humans, becomes excitotoxic when present outside of protein in excess of what the healthy human was designed to accommodate; amounts readily available to consumers who ingest multiple free-glutamate-containing ...
Adrienne Samuels
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Study of hepatic binding protein activity in jejuno‐ileal by‐passed rat hepatocytes [PDF]
FEBS Letters, 1985 The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno‐ileal by‐passed rat hepatocytes. In by‐passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3‐fold, without any modification of apparant constant of internalization.
Serbource-Goguel, Nathalie +5 more
openaire +2 more sources