Results 31 to 40 of about 303,050 (262)
Message-passing algorithms for the prediction of protein domain interactions from protein–protein interaction data [PDF]
Bioinformatics, 2008 Abstract Motivation: Cellular processes often hinge upon specific interactions among proteins, and knowledge of these processes at a system level constitutes a major goal of proteomics. In particular, a greater understanding of protein–protein interactions can be gained via a more detailed investigation of the protein domain interactions
Mudassar Iqbal +3 more
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eLife, 2022 Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs.
Dirk H Siepe +6 more
doaj +1 more source
You Shall Not Pass: MX2 Proteins Are Versatile Viral Inhibitors
Vaccines, 2023 Myxovirus resistance (MX) proteins are pivotal players in the innate immune response to viral infections. Less than 10 years ago, three independent groups simultaneously showed that human MX2 is an interferon (IFN)-stimulated gene (ISG) with potent anti-human immunodeficiency virus 1 (HIV-1) activity.
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Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel [PDF]
Cell, 2009 Most bacterial exported proteins cross the cytoplasmic membrane as unfolded polypeptides. However, little is known about how they fold during or after this process due to the difficulty in detecting folding intermediates. Here we identify cotranslational and posttranslational folding intermediates of a periplasmic protein in which the protein and DsbA,
Kadokura, Hiroshi, Beckwith, Jon
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Membranome 3.0: Database of single‐pass membrane proteins with
Protein Science, 2022 AbstractThe Membranome database provides comprehensive structural information on single‐pass (i.e., bitopic) membrane proteins from six evolutionarily distant organisms, including protein–protein interactions, complexes, mutations, experimental structures, and models of transmembrane α‐helical dimers.
Andrei L. Lomize +6 more
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Benchmarking subcellular localization and variant tolerance predictors on membrane proteins
BMC Genomics, 2019 Background Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments.
Tommaso Orioli, Mauno Vihinen
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Na+/Ca2+ selectivity in the bacterial voltage-gated sodium channel NavAb [PDF]
PeerJ, 2013 The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated.
Ben Corry
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
ReumatismoObjective. Patients Acceptable Symptom State (PASS) is a single dichotomized question assessing health satisfaction. We aimed to investigate PASS achievement within 4 weeks of treatment with Janus kinase (JAK) inhibitors (Jakinibs) and its association ...
C. Garufi +11 more
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Dose dependent toxicity of glutamic acid: a review
International Journal of Food Properties, 2020 L-glutamate, the major neurotransmitter in humans, becomes excitotoxic when present outside of protein in excess of what the healthy human was designed to accommodate; amounts readily available to consumers who ingest multiple free-glutamate-containing ...
Adrienne Samuels
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