Results 51 to 60 of about 4,912 (164)

IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS‐associated amyotrophic lateral sclerosis

Brain Pathology, Volume 34, Issue 1, January 2024.
FUS R521H motor neurons derived from IPSCs exhibit reduced viability, decreased protein synthesis, and diminished cytokine production when exposed to oxidative stress. Treatment with IFNy improves translation rates and mitigates apoptosis caused by oxidative injury.
Amanda Faria Assoni, Erika N. Guerrero, René Wardenaar, Danyllo Oliveira, Petra L. Bakker, Luciana M. Alves, Valdemir M. Carvalho, Oswaldo Keith Okamoto, Mayana Zatz, Floris Foijer   +9 more
wiley   +1 more source

Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects

Scientific Reports, 2017
Non-syndromic cleft lip and/or palate (NSCLP) is a common congenital malformation with a multifactorial model of inheritance. Although several at-risk alleles have been identified, they do not completely explain the high heritability.
Lucas Alvizi, Xiayi Ke, Luciano Abreu Brito, Rimante Seselgyte, Gudrun E. Moore, Philip Stanier, Maria Rita Passos-Bueno   +6 more
doaj   +1 more source

Ibrutinib Modulates Proliferation, Migration, Mitochondrial Homeostasis, and Apoptosis in Melanoma Cells

Biomedicines
Ibrutinib, a tyrosine kinase inhibitor with a broad spectrum of action, has been successfully explored to treat hematological and solid cancers. Herein, we investigated the anti-cancer effect of Ibrutinib on melanoma cell lines.
Fernanda Vitelli Lins, Elizabete Cristina Iseke Bispo, Naomí Souza Rodrigues, Maria Victória Souto Silva, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo   +6 more
doaj   +1 more source

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

Stem Cells International, 2017
Pericytes are important cellular components of the tumor microenviroment with established roles in angiogenesis and metastasis. These two cancer hallmarks are modulated by enzymes of the LOX family, but thus far, information about LOX relevance in tumor ...
Aline Lopes Ribeiro, Carolini Kaid, Patrícia B. G. Silva, Beatriz A. Cortez, Oswaldo Keith Okamoto   +4 more
doaj   +1 more source

Characterization of ibrutinib's effects on the morphology, proliferation, phenotype, viability, and anti-inflammatory potential of adipose-derived mesenchymal stromal cells

Scientific Reports
Ibrutinib (IB) is a tyrosine kinase inhibitor (TKI) that has immunomodulatory action and can be used as second-line therapy for steroid-refractory or steroid-resistant chronic Graft versus Host Disease (cGVHD).
Amandda Évelin Silva-Carvalho, Elizabete Cristina Iseke Bispo, Ingrid Gracielle Martins da Silva, José Raimundo Correa, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo   +6 more
doaj   +1 more source

Genetic heterogeneity in autosomal recessive hearing loss: a survey of Brazilian families

Frontiers in Genetics
IntroductionHearing loss is a frequent sensory impairment type in humans, with about 50% of prelingual cases being attributed to genetic factors. Autosomal recessive hearing loss (ARHL) exhibits great locus heterogeneity and is responsible for 70%–80% of
Larissa Nascimento Antunes, Alex Marcel Moreira Dias, Beatriz Cetalle Schiavo, Beatriz C. A. Mendes, Debora Romeo Bertola, Debora Romeo Bertola, Karina Lezirovitz, Regina Célia Mingroni-Netto   +7 more
doaj   +1 more source

Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived from a Schizophrenic Patient

Cell Transplantation, 2012
Schizophrenia has been defined as a neurodevelopmental disease that causes changes in the process of thoughts, perceptions, and emotions, usually leading to a mental deterioration and affective blunting.
Bruna Da Silveira Paulsen, Renata De Moraes Maciel, Antonio Galina, Mariana Souza Da Silveira, Cleide Dos Santos Souza, Hannah Drummond, Ernesto Nascimento Pozzatto, Hamilton Silva Junior, Leonardo Chicaybam, Raffael Massuda, Pedro Setti-Perdigão, Martin Bonamino, Paulo Silva Belmonte-De-Abreu, Newton Gonçalves Castro, Helena Brentani, Stevens Kastrup Rehen   +15 more
doaj   +1 more source

iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

Mediators of Inflammation, 2015
There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined.
Puebla Cassini-Vieira, Fernanda Assis Araújo, Filipi Leles da Costa Dias, Remo Castro Russo, Silvia Passos Andrade, Mauro Martins Teixeira, Luciola Silva Barcelos   +6 more
doaj   +1 more source

Combined Effects of Pericytes in the Tumor Microenvironment

Stem Cells International, 2015
Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of ...
Aline Lopes Ribeiro, Oswaldo Keith Okamoto   +1 more
doaj   +1 more source

Common mental disorders in hematopoietic stem cell transplant patients: a scoping review. [PDF]

Rev Bras Enferm, 2023
Almeida ACP, Azevedo VD, Alves TRM, Santos VEP, Silva GWDS, Azevedo IC.   +5 more
europepmc   +1 more source