Results 81 to 90 of about 21,599 (233)

Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations

Epigenetics
While genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability.
Camila Cristina Avila Martins, Mariana Maschietto, Lilian Kimura, Lucas Alvizi, Kelly Nunes, Vinícius Magalhães Borges, Ana Cristina Victorino Krepischi, Regina Célia Mingroni-Netto   +7 more
doaj   +1 more source

Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived from a Schizophrenic Patient

Cell Transplantation, 2012
Schizophrenia has been defined as a neurodevelopmental disease that causes changes in the process of thoughts, perceptions, and emotions, usually leading to a mental deterioration and affective blunting.
Bruna Da Silveira Paulsen, Renata De Moraes Maciel, Antonio Galina, Mariana Souza Da Silveira, Cleide Dos Santos Souza, Hannah Drummond, Ernesto Nascimento Pozzatto, Hamilton Silva Junior, Leonardo Chicaybam, Raffael Massuda, Pedro Setti-Perdigão, Martin Bonamino, Paulo Silva Belmonte-De-Abreu, Newton Gonçalves Castro, Helena Brentani, Stevens Kastrup Rehen   +15 more
doaj   +1 more source

Partially matched family donor allogeneic bone marrow transplantation [PDF]

, 2010
O transplante de células-tronco hematopoéticas alogênico (TCTH alo) após um regime de condicionamento ablativo ou não mieloablativo é um tratamento potencialmente curativo para uma grande variedade de doenças malignas hematológicas e outras desordens não
DULLEY, Frederico L., FERREIRA, Euripedes, SABOYA, Rosaura, SIMÕES, Belinda   +3 more
core   +1 more source

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

Stem Cells International, 2017
Pericytes are important cellular components of the tumor microenviroment with established roles in angiogenesis and metastasis. These two cancer hallmarks are modulated by enzymes of the LOX family, but thus far, information about LOX relevance in tumor ...
Aline Lopes Ribeiro, Carolini Kaid, Patrícia B. G. Silva, Beatriz A. Cortez, Oswaldo Keith Okamoto   +4 more
doaj   +1 more source

Terapêutica modificadora da esclerose múltipla: presente e perspectivas futuras [PDF]

, 2016
Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraA esclerose múltipla (EM) é a doença neurológica incapacitante mais comum nos ...
Chaves, Laura Sofia da Silva
core  

Brazilian consensus meeting on stem cell transplantation: hemoglobinopathies comittee [PDF]

, 2010
Os distúrbios hereditários das hemoglobinas são as doenças genéticas mais frequentes do homem e mais difundidas no mundo, abrangendo sobretudo continentes como África, Américas, Europa e extensas regiões da Ásia.
ANGULO, Ivan, BARROS, George M. N., CANÇADO, Rodolfo D., MACHADO, Clarisse L., PIERONI, Fabiano, SALVINO, Marco Aurélio, SIMÕES, Belinda P., VOLTARELLI, Julio Cesar   +7 more
core   +1 more source

Characterization of ibrutinib's effects on the morphology, proliferation, phenotype, viability, and anti-inflammatory potential of adipose-derived mesenchymal stromal cells

Scientific Reports
Ibrutinib (IB) is a tyrosine kinase inhibitor (TKI) that has immunomodulatory action and can be used as second-line therapy for steroid-refractory or steroid-resistant chronic Graft versus Host Disease (cGVHD).
Amandda Évelin Silva-Carvalho, Elizabete Cristina Iseke Bispo, Ingrid Gracielle Martins da Silva, José Raimundo Correa, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo   +6 more
doaj   +1 more source

Genetic heterogeneity in autosomal recessive hearing loss: a survey of Brazilian families

Frontiers in Genetics
IntroductionHearing loss is a frequent sensory impairment type in humans, with about 50% of prelingual cases being attributed to genetic factors. Autosomal recessive hearing loss (ARHL) exhibits great locus heterogeneity and is responsible for 70%–80% of
Larissa Nascimento Antunes, Alex Marcel Moreira Dias, Beatriz Cetalle Schiavo, Beatriz C. A. Mendes, Debora Romeo Bertola, Debora Romeo Bertola, Karina Lezirovitz, Regina Célia Mingroni-Netto   +7 more
doaj   +1 more source

Writing a novel, chapter one: precedents and decision process in the Brazilian Supreme Court [PDF]

, 2009
O artigo, por meio do estudo de casos exemplificativos, procura mostrar que um dos motivos para a falta de uma cultura de respeito aos precedentes judiciais no Supremo Tribunal Federal (STF), ou para a falta de um romance em cadeia (Dworkin), é a ...
CARDOSO, Evorah Lusci Costa, MACHADO, Ana Mara França, VOJVODIC, Adriana de Moraes   +2 more
core   +2 more sources

Combined Effects of Pericytes in the Tumor Microenvironment

Stem Cells International, 2015
Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of ...
Aline Lopes Ribeiro, Oswaldo Keith Okamoto   +1 more
doaj   +1 more source