Results 51 to 60 of about 7,255 (192)

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

More than Enzymes That Make or Break Cyclic Di-GMP—Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli

mBio, 2017
The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains)
Olga Sarenko, Gisela Klauck, Franziska M. Wilke, Vanessa Pfiffer, Anja M. Richter, Susanne Herbst, Volkhard Kaever, Regine Hengge   +7 more
doaj   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism

Cell Reports
Summary: Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that governs the lifestyle switch between planktonic and biofilm states.
Corey Kennelly, Peter Tran, Arthur Prindle   +2 more
doaj   +1 more source

Socializing, networking and development: a report from the second ‘Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis’ [PDF]

, 2012
In mid-June, the second Young Microbiologists Symposium took place under the broad title of ‘Microbe signalling, organization and pathogenesis’ on the picturesque campus of University College Cork, Ireland.
Barret, Brackman, Brown, Bush, Cascales, Corrigan, Costerton, Coulthurst, D'Autreaux, Davey, Delalez, Fazli, Gerlach, Hagan, Holland, Hood, Housden, Kleanthous, Kuchma, Kuchma, Kuchma, Lawley, Lebeer, Malone, McCarthy, Merritt, Murdoch, O'Connell Motherway, O'Connell Motherway, O'Toole, Porter, Ramsay, Ramsay, Rigel, Roberts, Ryan, Ryan, Ryan, Ryan, Ryan, Schwarz, Sharma, Shioya, Smith, Thompson, Twomey, Waters, Yang, Youle   +48 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators [PDF]

, 2017
The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway
Abel, Abel, Aldridge, Aldridge, Altschul, Attmannspacher, Baker, Belas, Berg, Boehm, Bond, Bourret, Bren, Briegel, Burkart, Chen, Chevance, Cho, Chou, Christen, Christen, Christen, Crooks, Davis, Deshpande, Dufour, Ely, Ely, Fang, Ferré, Finn, Galperin, Gao, Girgis, Habazettl, Harshey, Harshey, Hazelbauer, Hoffman, Hug, Jenal, Jenal, Jones, Karimova, Kawagishi, Kojima, Koyasu, Krell, Kulasekara, Lasker, Laventie, Lee, Li, Liu, Lori, Misselwitz, Molaei, Mukherjee, Nesper, Nierman, Parkinson, Paul, Persat, Pilizota, Porter, Porter, Porter, Russell, Sarkar, Scharf, Schneider, Schrader, Segata, Skerker, Sklenár, Smith, Sonnhammer, Sourjik, Steiner, Tindall, UniProt Consortium, Vacic, Volkman, Wang, Welch, Wolfe, Xie, Xu, Zhou, Zhou   +89 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Elevated intracellular cyclic‐di‐GMP level in Shewanella oneidensis increases expression of c‐type cytochromes

Microbial Biotechnology, 2020
Summary Electrochemically active biofilms are capable of exchanging electrons with solid electron acceptors and have many energy and environmental applications such as bioelectricity generation and environmental remediation.
Chun Kiat Ng, Jiabao Xu, Zhao Cai, Liang Yang, Ian P. Thompson, Wei E. Huang, Bin Cao   +6 more
doaj   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source