A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines [PDF]
, 2012 An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl ...
Chuang, Kangway V. +2 more
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Phosphine-free palladium-catalysed direct C2-arylation of benzothiophenes with aryl bromides [PDF]
, 2013 Copies of 1H and 13C NMR spectra of new compounds are available (attached file).International audienceLigand-free Pd(OAc)2 was found to catalyse very efficiently the direct C2-arylation of benzothiophene derivatives under low catalyst concentration.
Bruneau, Christian +2 more
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Communications ChemistryUsing Pd homogeneous catalysts for direct C–H arylation is an attractive approach for synthesizing natural products and organic functional materials, but limitations in terms of cost and catalyst recovery could be alleviated by alternative heterogeneous ...
Xiaojie He +6 more
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Journal of Enzyme Inhibition and Medicinal ChemistryPhenols are important structural elements of natural products and pharmaceuticals. Due to their versatile chemical transformability, phenols are frequently used building blocks in medicinal chemistry.
Rebeka Ignácz +8 more
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Push-pull bithiophene azo-chromophores bearing thiazole and benzothiazole acceptor moieties: synthesis and evaluation of their redox and nonlinear optical properties [PDF]
, 2011 Three series of bithiophene azo dyes functionalized with thiazol-2-yl or benzothiazol-2-yl-diazene acceptor moieties were synthesized through azo coupling reaction using 2,2´-bithiophene, 5-alkoxy-2,2´-bithiophenes, 5-N,N-dialkylamino-2,2´-bithiophenes ...
Belsley, M. +3 more
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Birch reductive arylation by mechanochemical anionic activation of polycyclic aromatic compounds
Nature CommunicationsBirch reduction is a well-known process for transforming aromatic compounds. The reduction of aromatic rings using alkali metals produces anionic species that react with protons or electrophiles.
Yoshifumi Toyama +3 more
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Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
Nature Communications, 2016 Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with ...
Jonathan Latham +6 more
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Palladium-catalyzed C(sp^3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids [PDF]
, 2016 A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-
Chen, Kai +3 more
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Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
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Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials [PDF]
, 2019 Electrochemical hydrogenation has emerged as an environmentally benign and operationally simple alternative to traditional catalytic reduction of organic compounds.
Ge, Haibo, Li, Bijin
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